Cardiopulmonary adjustments during exercise and an aversive reaction time task: effects of beta-adrenoceptor blockade.
Cardiopulmonary adjustments during exercise and an aversive reaction time task: effects of beta-adrenoceptor blockade.
复制标题
运动期间的心肺调整和厌恶反应时间任务：β-肾上腺素受体阻断的影响。
DOI：
10.1111/j.1469-8986.1985.tb01561.x
复制
发表时间：
1985
期刊：
影响因子：
3.7
通讯作者：
Obrist,PA
中科院分区：
文献类型：
--
作者：
Langer,AW;McCubbin,JA;Stoney,CM;Hutcheson,JS;Charlton,JD;Obrist,PA
这项研究的目的是比较身体(自行车运动)和行为(厌恶反应时间)应激源对心肺和血流动力学的调整。一个相关的目的是评估β-肾上腺素能机制在调节这些生理反应中的作用。34名受试者同时暴露在两种应激源下，同时计算氧耗量、二氧化碳产生、肺通气量、呼气末氧气和二氧化碳以及心率。其中14名受试者接受了4 mg(Iv)的盐酸心得安的预治疗。剩下的20名受试者(完好无损)根据他们对反应时间任务的心率反应被细分为10个反应最多的和10个反应最少的。结果表明，对于正常组，运动和反应时间任务都显着增加了心率，尽管心率变化的幅度在运动过程中确实更大。阻断β-肾上腺素能部分减弱运动所致的心动过速，但完全消除行为应激所致的心动过速。有趣的是，反应最多和反应最少的受试者在运动过程中没有表现出不同的心率加速，尽管在反应时间任务中存在可靠的差异。在运动中，氧耗量显着增加到可预测的水平，但在反应时间任务中，反应最多和最不反应的组都没有改变。这些结果表明，反应性受试者在反应时间任务中引发的心动过速与相对于运动的氧耗量的适当增加无关，因此可能预示着全身过度灌流。
The purpose of this study was to compare the cardiopulmonary and hemodynamic adjustments to a physical (bicycle exercise) and behavioral (aversive reaction time) stressor. A related aim was to assess the role of beta‐adrenergic mechanisms in mediating these physiological responses. Thirty‐four subjects were exposed to both stressors while oxygen consumption, carbon dioxide production, pulmonary ventilation, end‐tidal oxygen and carbon dioxide, as well as heart rate were calculated breath‐by‐breath. Fourteen of these subjects were pretreated with 4 mg (iv) of propranolol hydrochloride. The remaining 20 subjects (intact) were subdivided post‐hoc into the 10 most and 10 least reactive on the basis of their heart rate response to the reaction time task. The results indicate that for the intact group both exercise and the reaction time task produced significant increases in heart rate although the magnitude of the heart rate change was reliably greater during exercise. Beta‐adrenergic blockade partially diminished the tachycardia to exercise but entirely abolished the tachycardia to behavioral stress. Interestingly, the most and least reactive subjects did not exhibit differential heart rate acceleration during exercise despite a reliable difference during the reaction time task. Oxygen consumption significantly increased to predictable levels during exercise but failed to change during the reaction time task for both the most and least reactive groups. These results suggest that the tachycardia elicited by the reaction time task in reactive subjects was not associated with an appropriate increase in oxygen consumption, relative to exercise, and may therefore be indicative of systemic overperfusion.
登录
查看更多内容
影响因子：
20.1
作者：
T. Coleman;H. Granger;A. C. Guyton
通讯作者：
A. C. Guyton
健康受试者坐位运动期间的β-肾上腺素能阻断和中枢循环。
DOI：
10.1111/j.1365-201x.1968.tb10883.x
发表时间：
1968
期刊：
Acta physiologica Scandinavica
影响因子：
--
作者：
C. Furberg;G. von Schmalensee
通讯作者：
G. von Schmalensee
人类急性应激期间交感神经对心率和收缩力的影响。
影响因子：
3.7
作者：
P. Obrist;James E. Lawler;James L. Howard;Kenneth W. Smithson;Philip L. Martin;John Manning
通讯作者：
John Manning
β-阻断和情绪性心动过速；
影响因子：
3.3
作者：
P. Imhof;K. Blatter;L. Fuccella;M. Turri
通讯作者：
M. Turri
DOI：
10.1097/00005053-195202000-00004
发表时间：
1952
期刊：
The Journal of nervous and mental disease
影响因子：
--
作者：
H. Jost;C. J. Ruilmann;T. S. Hill;M. Gulo
通讯作者：
M. Gulo