Cancer Drug Delivery Systems Using Bacterial Toxin Translocation Mechanisms.
Cancer Drug Delivery Systems Using Bacterial Toxin Translocation Mechanisms.
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DOI：
10.3390/bioengineering10070813
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发表时间：
2023-07-07
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影响因子：
--
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靶向癌症治疗的最新进展为研究和临床应用带来了巨大的希望，并推动了寻找各种目前无法治愈的癌症的新治疗方法的界限。然而，这些疗法需要特定的细胞靶向机制，以便有效地将药物货物穿过细胞膜到达细胞内目标，避免扩散到不需要的组织。传统的给药系统在跨越细胞膜屏障的能力有限，因此需要高剂量，这与不良反应和安全问题有关。细菌毒素通过其受体结合模块自然地进化为特异性靶向细胞亚型，通过膜易位过程有效地穿透细胞膜，然后成功地将有毒货物运送到宿主细胞质中。因此，它们被用来运送各种药物。本文综述了炭疽毒素保护抗原、白喉毒素、白喉毒素的受体结合和膜易位过程对肿瘤治疗药物靶向递送系统的影响，并对细菌毒素的易位机制和最新进展进行了综述。我们还讨论了这些研究的挑战和局限性，在基于细菌毒素的药物传递系统成为临床翻译中可行的新一代药物传递方法之前应该解决这些问题。
Recent advances in targeted cancer therapy hold great promise for both research and clinical applications and push the boundaries in finding new treatments for various currently incurable cancers. However, these therapies require specific cell-targeting mechanisms for the efficient delivery of drug cargo across the cell membrane to reach intracellular targets and avoid diffusion to unwanted tissues. Traditional drug delivery systems suffer from a limited ability to travel across the barriers posed by cell membranes and, therefore, there is a need for high doses, which are associated with adverse reactions and safety concerns. Bacterial toxins have evolved naturally to specifically target cell subtypes via their receptor binding module, penetrating the cell membrane efficiently through the membrane translocation process and then successfully delivering the toxic cargo into the host cytosol. They have, thus, been harnessed for the delivery of various drugs. In this review, we focus on bacterial toxin translocation mechanisms and recent progress in the targeted delivery systems of cancer therapy drugs that have been inspired by the receptor binding and membrane translocation processes of the anthrax toxin protective antigen, diphtheria toxin, and Pseudomonas exotoxin A. We also discuss the challenges and limitations of these studies that should be addressed before bacterial toxin-based drug delivery systems can become a viable new generation of drug delivery approaches in clinical translation.
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影响因子：
56.9
作者：
Dong, M;Yeh, F;Chapman, ER
通讯作者：
Chapman, ER
DOI：
10.1111/j.1749-6632.1960.tb20099.x
发表时间：
1960-01-01
期刊：
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES-SERIES
影响因子：
--
作者：
BARKSDALE, L;GARMISE, L;HORIBATA, K
通讯作者：
HORIBATA, K
DOI：
10.1016/j.str.2020.05.009
发表时间：
2020-08-04
期刊：
Structure (London, England : 1993)
影响因子：
--
作者：
Zhou K;Liu S;Hardenbrook NJ;Cui Y;Krantz BA;Zhou ZH
通讯作者：
Zhou ZH
影响因子：
64.8
作者：
CHOE, S;BENNETT, MJ;EISENBERG, D
通讯作者：
EISENBERG, D
影响因子：
6.4
作者：
Ferlay, Jacques;Colombet, Murielle;Bray, Freddie
通讯作者：
Bray, Freddie