Risk factors of amyotrophic lateral sclerosis: a global meta-summary.
Risk factors of amyotrophic lateral sclerosis: a global meta-summary.
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DOI：
10.3389/fnins.2023.1177431
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发表时间：
2023
影响因子：
4.3
通讯作者：
Chen, Yong-Ping
中科院分区：
文献类型：
--
作者：
Duan, Qing-Qing;Jiang, Zheng;Su, Wei-Ming;Gu, Xiao-Jing;Wang, Han;Cheng, Yang-Fan;Cao, Bei;Gao, Xia;Wang, Yi;Chen, Yong-Ping
肌萎缩性侧索硬化症（ALS）的病因在很大程度上仍然未知。本研究旨在总结ALS与其遗传和非遗传危险因素的关系。检索PubMed、Embase和Cochrane数据库自成立至2022年12月的相关文献。随机效应或固定效应模型采用Stata MP 15.0来合并多变量或调整比率（or）。普洛斯彼罗注册号：CRD42022301549。纳入230项符合条件的研究，其中67项涉及22个非遗传因素，163项涉及遗传因素。分析了非遗传因素的四个方面，包括生活方式、环境和职业暴露、已有疾病/合并症和医疗暴露等。暴露于重金属(或= 1.79),农药(或= 1.46),溶剂(或= 1.37),以前的头部创伤(或= 1.37),兵役(或= 1.29),中风(或= 1.26),磁场(或= 1.22)和高血压(或= 1.04)是重要的风险因素,但抗糖尿病药的使用(或= 0.52),高BMI(或= 0.60肥胖和超重的比正常,体重不足),生活在城市(或= 0.70),糖尿病(或= 0.83),肾脏疾病(或= 0.84)减少患肌萎缩性侧索硬化症。此外，我们还对8个常见的ALS相关基因进行了评估，这些基因的突变频率从高到低依次为SOD1（2.2%）、C9orf72（2.1%）、ATXN2（1.7%）、FUS（1.7%）、TARDBP（0.8%）、VCP（0.6%）、UBQLN2（0.6%）和SQSTM1（0.6%）。我们的研究结果表明，有效的风险暴露干预和及时改变生活方式可能预防ALS的发生。基因突变是ALS的重要危险因素，正确、科学地检测基因突变至关重要。https://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=301549，标识符：CRD42022301549。
The etiology of amyotrophic lateral sclerosis (ALS) remains largely unknown. This study aimed to summarize the relationship between ALS and its genetic and non-genetic risk factors. A search of relevant literature from PubMed, Embase, and Cochrane Database from inception to December 2022 was performed. Random-effects or fixed-effects models were performed by Stata MP 15.0 to pool multivariate or adjusted ratios (OR). PROSPERO registration number: CRD42022301549. 230 eligible studies were included, of which 67 involved 22 non-genetic factors, and 163 involved genetic factors. Four aspects of non-genetic factors, including lifestyle, environmental and occupational exposures, pre-existing diseases/comorbidity and medical exposures, and others, were analyzed. Exposure to heavy metals (OR = 1.79), pesticides (OR = 1.46), solvents (OR = 1.37), previous head trauma (OR = 1.37), military service (OR = 1.29), stroke (OR = 1.26), magnetic field (OR = 1.22) and hypertension (OR = 1.04) are significant risk factors, but use of antidiabetics (OR = 0.52), high BMI (OR = 0.60 for obese and overweight vs. normal and underweight), living in urban (OR = 0.70), diabetes mellitus (OR = 0.83), and kidney disease (OR = 0.84) decrease the risk for ALS. In addition, eight common ALS-related genes were evaluated, the mutation frequencies of these genes were ranked from highest to lowest as SOD1 (2.2%), C9orf72 (2.1%), ATXN2 (1.7%), FUS (1.7%), TARDBP (0.8%), VCP (0.6%), UBQLN2(0.6%) and SQSTM1 (0.6%) in all the ALS patients. Our findings suggested that effective intervention for risk exposure and timely modification of lifestyle might prevent the occurrence of ALS. Genetic mutations are important risk factors for ALS and it is essential to detect genetic mutations correctly and scientifically. https://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=301549, identifier: CRD42022301549.
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影响因子：
48
作者：
Goutman, Stephen A.;Hardiman, Orla;Al-Chalabi, Ammar;Chio, Adriano;Savelieff, Masha G.;Kiernan, Matthew C.;Feldman, Eva L.
通讯作者：
Feldman, Eva L.
DOI：
10.1136/bmj.b2535
发表时间：
2009-07-21
期刊：
BMJ (Clinical research ed.)
影响因子：
--
作者：
Moher D;Liberati A;Tetzlaff J;Altman DG;PRISMA Group
通讯作者：
PRISMA Group
影响因子：
5.5
作者：
Ferri L;Ajdinaj P;Rispoli MG;Carrarini C;Barbone F;D'Ardes D;Capasso M;Muzio AD;Cipollone F;Onofrj M;Bonanni L
通讯作者：
Bonanni L
影响因子：
4.9
作者：
Dickerson, Aisha S.;Hansen, Johnni;Weisskopf, Marc G.
通讯作者：
Weisskopf, Marc G.
影响因子：
3.8
作者：
Ash, Peter E. A.;Dhawan, Uma;Wolozin, Benjamin
通讯作者：
Wolozin, Benjamin