Immunomodulatory and Anti-Inflammatory Properties of Selenium-Containing Agents: Their Role in the Regulation of Defense Mechanisms against COVID-19.
Immunomodulatory and Anti-Inflammatory Properties of Selenium-Containing Agents: Their Role in the Regulation of Defense Mechanisms against COVID-19.
复制标题
含硒药物的免疫调节和抗炎特性：它们在调节COVID-19防御机制中的作用。
DOI：
10.3390/ijms23042360
复制
发表时间：
2022-02-21
影响因子：
5.6
通讯作者：
Varlamova EG
中科院分区：
文献类型：
--
作者：
Mal'tseva VN;Goltyaev MV;Turovsky EA;Varlamova EG
综述了含硒制剂在免疫系统疾病调节中的作用的最新数据。我们主要考虑了含硒化合物，如亚硒酸钠，甲基亚硒酸，硒代蛋氨酸和甲基硒代半胱氨酸，以及硒蛋白和硒纳米颗粒在调节各种病毒感染，包括冠状病毒感染（COVID-19）的防御机制中的贡献。完整描述了上述硒化合物中每一种的可用数据，以及这些硒制剂积极参与免疫过程调节的机制，以及它们的治疗和药理学潜力。本综述的主要目的是将现有的信息系统化，并辅以我们实验室获得的数据，说明硒化合物在所有这些过程中的重要作用。此外，所提供的信息使人们有可能了解这些化合物作用机制的关键差异，这取决于它们的化学和物理特性，这对于获得基于它们的药物的整体图像和前景非常重要。
The review presents the latest data on the role of selenium-containing agents in the regulation of diseases of the immune system. We mainly considered the contributions of selenium-containing compounds such as sodium selenite, methylseleninic acid, selenomethionine, and methylselenocysteine, as well as selenoproteins and selenium nanoparticles in the regulation of defense mechanisms against various viral infections, including coronavirus infection (COVID-19). A complete description of the available data for each of the above selenium compounds and the mechanisms underlying the regulation of immune processes with the active participation of these selenium agents, as well as their therapeutic and pharmacological potential, is presented. The main purpose of this review is to systematize the available information, supplemented by data obtained in our laboratory, on the important role of selenium compounds in all of these processes. In addition, the presented information makes it possible to understand the key differences in the mechanisms of action of these compounds, depending on their chemical and physical properties, which is important for obtaining a holistic picture and prospects for creating drugs based on them.
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