The association between hantavirus infection and selenium deficiency in mainland China.
The association between hantavirus infection and selenium deficiency in mainland China.
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中国大陆汉坦病毒感染与缺硒的关系
DOI：
10.3390/v7010333
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发表时间：
2015-01-20
期刊：
影响因子：
--
通讯作者：
de Vlas SJ
中科院分区：
文献类型：
--
作者：
Fang LQ;Goeijenbier M;Zuo SQ;Wang LP;Liang S;Klein SL;Li XL;Liu K;Liang L;Gong P;Glass GE;van Gorp E;Richardus JH;Ma JQ;Cao WC;de Vlas SJ
由汉坦病毒引起的由啮齿动物传播的肾综合征出血热是中国地区的重大公共卫生问题，在缺硒地区发病率较高。为了研究硒浓度在肾综合征出血热发病中的作用，我们采用了生态分析和初步实验数据相结合的多学科方法。与非缺硒地区相比，严重缺硒地区的人患肾综合征出血热的发病率高出约6倍，中度缺硒地区的发病率高出一倍。在对其他与环境有关的重要因素(低海拔、少草原或森林丰富)进行校正后，这种关联性在统计上变得更强，而且通过对不同气候区域的单独分析，这种关联性独立于地理规模。一项对入院的HFRS患者进行的病例对照研究显示，在感染低感染复数(MOI)的内皮细胞模型中，硒结合蛋白的活性和血浆水平增加，而体外补硒则降低了病毒复制。补硒不影响MOI较高的病毒复制。我们的发现表明，缺硒可能导致汉坦病毒感染在人类和啮齿动物中的流行率增加。在缺硒地区实施补硒以预防肾综合征出血热之前，需要进一步研究这一观察结果背后的确切机制。
Hemorrhagic fever with renal syndrome (HFRS) caused by hantaviruses and transmitted by rodents is a significant public health problem in China, and occurs more frequently in selenium-deficient regions. To study the role of selenium concentration in HFRS incidence we used a multidisciplinary approach combining ecological analysis with preliminary experimental data. The incidence of HFRS in humans was about six times higher in severe selenium-deficient and double in moderate deficient areas compared to non-deficient areas. This association became statistically stronger after correction for other significant environment-related factors (low elevation, few grasslands, or an abundance of forests) and was independent of geographical scale by separate analyses for different climate regions. A case-control study of HFRS patients admitted to the hospital revealed increased activity and plasma levels of selenium binding proteins while selenium supplementation in vitro decreased viral replication in an endothelial cell model after infection with a low multiplicity of infection (MOI). Viral replication with a higher MOI was not affected by selenium supplementation. Our findings indicate that selenium deficiency may contribute to an increased prevalence of hantavirus infections in both humans and rodents. Future studies are needed to further examine the exact mechanism behind this observation before selenium supplementation in deficient areas could be implemented for HFRS prevention.
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