Subjective and physiological effects of acute intranasal methamphetamine during d-amphetamine maintenance.
Subjective and physiological effects of acute intranasal methamphetamine during d-amphetamine maintenance.
复制标题
d-苯丙胺维持期间急性鼻内甲基苯丙胺的主观和生理效应。
DOI：
10.1007/s00213-010-2067-5
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发表时间：
2011
影响因子：
3.4
通讯作者：
Hays,LonR
中科院分区：
文献类型：
--
作者：
Rush,CraigR;Stoops,WilliamW;Lile,JoshuaA;Glaser,PaulEA;Hays,LonR
RationaleMethamphetamine abuse and dependence are significant public-health concerns. Behavioral therapies are effective for reducing methamphetamine use. However, many patients enrolled in behavioral therapies are unable to achieve significant periods of abstinence, suggesting other strategies like pharmacotherapy are needed.ObjectivesThis experiment determined the subjective and physiological effects of intranasal methamphetamine duringd-amphetamine maintenance in eight non-treatment-seeking stimulant-dependent participants. We predictedd-amphetamine maintenance would attenuate the acute subjective effects of intranasal methamphetamine. We also predicted intranasal methamphetamine would be well tolerated duringd-amphetamine maintenance.MethodsAfter at least 7 days of maintenance on sustained-released-amphetamine (0 and 45 mg/day), participants were administered ascending doses of intranasal methamphetamine (0, 2.5, 5, 10, and 20 mg) across two experimental sessions. Intranasal methamphetamine doses were separated by 90 min.ResultsIntranasal methamphetamine produced prototypical subjective and physiological effects (e.g., increased ratings of Like Drug; increased heart rate, blood pressure, and body temperature). The acute effects of intranasal methamphetamine were significantly diminished duringd-amphetamine maintenance relative to placebo maintenance.ConclusionsThese results are concordant with those of clinical trials and provide further support for the use of agonist replacement therapy to manage methamphetamine dependence. Additional research in humans is needed to determine the effectiveness ofd-amphetamine under different experimental conditions that more closely reflect use in the natural environment (e.g., higher methamphetamine doses) and behavioral arrangements that are predictive of pharmacotherapy effectiveness (e.g., drug self-administration).
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影响因子：
2.9
作者：
Rush, Craig R.;Stoops, William W.;Hays, Lon R.
通讯作者：
Hays, Lon R.
凝视时间是可卡因相关注意力偏差的敏感衡量指标
影响因子：
4.2
作者：
Katherine R. Marks;W. Stoops;E. Pike;Walter Roberts;M. Fillmore;C. Rush
通讯作者：
C. Rush
影响因子：
4.2
作者：
Hester, R;Dixon, V;Garavan, H
通讯作者：
Garavan, H
影响因子：
4.2
作者：
Rush CR;Stoops WW
通讯作者：
Stoops WW
影响因子：
6
作者：
Rawson, RA;Marinelli-Casey, P;Zweben, J
通讯作者：
Zweben, J