Antibody Titer Kinetics and SARS-CoV-2 Infections Six Months after Administration with the BNT162b2 Vaccine.
Antibody Titer Kinetics and SARS-CoV-2 Infections Six Months after Administration with the BNT162b2 Vaccine.
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DOI：
10.3390/vaccines9111357
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发表时间：
2021-11-19
期刊：
影响因子：
7.8
通讯作者：
Banfi G
中科院分区：
文献类型：
--
作者：
Ferrari D;Clementi N;Criscuolo E;Ambrosi A;Corea F;Di Resta C;Tomaiuolo R;Mancini N;Locatelli M;Plebani M;Banfi G
背景资料：报告接种BNT 162 b2 COVID-19疫苗后长期体液反应的研究对于推动未来的疫苗接种策略非常重要。然而，现有的文献很少。Covidiagnostix是一项多中心研究，旨在评估接受BNT 162 b2疫苗的>1000名医疗保健专业人员（HCP）的抗体应答。方法：分别在时间0（T0）、首次给药前、T1、T2和T3、T0后21、42和180天检测血清。测量针对SARS-CoV-2核衣壳蛋白的抗体以评估SARS-CoV-2感染，而测量针对刺突蛋白的受体结合结构域的抗体以评估疫苗应答。还分析了针对D 614 G、B.1.1.7和B.1.351变体的中和活性。结果如下：接种后6个月，HCP显示抗体滴度下降约70%，但滴度仍比接种前血清阳性个体高一个数量级。我们确定了12例疫苗接种后感染的HCP。没有人表现出严重的症状。有趣的是，它们中的大多数在T2时显示出高于从中和活性实验获得的中和阈值的滴度。结论：疫苗接种诱导体液应答，即使在疫苗接种后6个月也可检测到。接种疫苗可以预防严重的COVID-19病例，但即使在抗S血清抗体滴度较高的情况下，也可能发生接种后感染。
Background: Studies reporting the long-term humoral response after receiving the BNT162b2 COVID-19 vaccine are important to drive future vaccination strategies. Yet, available literature is scarce. Covidiagnostix is a multicenter study designed to assess the antibody response in >1000 healthcare professionals (HCPs) who received the BNT162b2 vaccine. Methods: Serum was tested at time-0 (T0), before the first dose, T1, T2, and T3, respectively, 21, 42, and 180 days after T0. Antibodies against the SARS-CoV-2 nucleocapsid-protein were measured to assess SARS-CoV-2 infections, whereas antibodies against the receptor-binding domain of the spike protein were measured to assess the vaccine response. Neutralization activity against the D614G, B.1.1.7, and B.1.351 variants were also analyzed. Results: Six months post-vaccination HCPs showed an antibody titer decrease of approximately 70%, yet, the titer was still one order of magnitude higher than that of seropositive individuals before vaccination. We identified 12 post-vaccination infected HCPs. None showed severe symptoms. Interestingly, most of them showed titers at T2 above the neutralization thresholds obtained from the neutralization activity experiments. Conclusion: Vaccination induces a humoral response which is well detectable even six months post-vaccination. Vaccination prevents severe COVID-19 cases, yet post-vaccination infection is possible even in the presence of a high anti-S serum antibody titer.
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BNT162B2 mRNA COVID-19疫苗的安全性和功效。
DOI：
10.1056/nejmoa2034577
发表时间：
2020-12-31
期刊：
The New England journal of medicine
影响因子：
--
作者：
Polack FP;Thomas SJ;Kitchin N;Absalon J;Gurtman A;Lockhart S;Perez JL;Pérez Marc G;Moreira ED;Zerbini C;Bailey R;Swanson KA;Roychoudhury S;Koury K;Li P;Kalina WV;Cooper D;Frenck RW Jr;Hammitt LL;Türeci Ö;Nell H;Schaefer A;Ünal S;Tresnan DB;Mather S;Dormitzer PR;Şahin U;Jansen KU;Gruber WC;C4591001 Clinical Trial Group
通讯作者：
C4591001 Clinical Trial Group
DOI：
10.1016/j.cca.2021.04.006
发表时间：
2021-08
期刊：
Clinica chimica acta; international journal of clinical chemistry
影响因子：
--
作者：
Padoan A;Dall'Olmo L;Rocca FD;Barbaro F;Cosma C;Basso D;Cattelan A;Cianci V;Plebani M
通讯作者：
Plebani M
影响因子：
64.8
作者：
Mulligan, Mark J.;Lyke, Kirsten E.;Jansen, Kathrin U.
通讯作者：
Jansen, Kathrin U.
影响因子：
6.8
作者：
Ferrari, Davide;Mangia, Alessandra;De Vecchi, Elena
通讯作者：
De Vecchi, Elena
影响因子：
7.8
作者：
Di Resta C;Ferrari D;Viganò M;Moro M;Sabetta E;Minerva M;Ambrosio A;Locatelli M;Tomaiuolo R
通讯作者：
Tomaiuolo R