Coherence-Weighted Synthetic Focusing Applied to Photoacoustic Imaging Using a High-Frequency Annular-Array Transducer.
Coherence-Weighted Synthetic Focusing Applied to Photoacoustic Imaging Using a High-Frequency Annular-Array Transducer.
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DOI：
10.1177/0161734615583981
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发表时间：
2016-01
影响因子：
2.3
通讯作者：
Ketterling JA
中科院分区：
文献类型：
--
作者：
Chitnis PV;Aristizábal O;Filoux E;Sampathkumar A;Mamou J;Ketterling JA
本文提出了一种自适应合成聚焦方案，当应用于光声（PA）数据采集使用环形阵列，提高了聚焦在更大的成像深度，提高了空间分辨率。成像系统基于一个40 MHz、5元件、环形阵列换能器，焦距为12 mm，中心元件有一个直径为800 μm的孔，便于532 nm激光的同轴传输。对换能器进行光栅扫描，以便于共配准超声和PA图像数据的3D采集。三个合成聚焦方案进行了比较，以获得PA的A线的每个扫描位置：延迟和总和（DAS），DAS加权的相干因子（DAS + CF），DAS加权的符号相干因子（DAS + SCF）。进行了使用80 μm头发的台式实验，以评估两种基于相干性的方案所提供的增强。两种基于相干性的方案都将信噪比提高了约10 dB。当使用仅DAS方案进行处理时，在具有20 dB动态范围的PA图像中，对于8至20 mm的成像深度范围，毛发的横向尺寸在300 μm至1 mm之间。相比之下，DAS + CF方案在相同范围内产生200至450 μm的横向尺寸。DAS + SCF合成聚焦进一步提高了最小可分辨尺寸，在相同的成像深度范围内，最小可分辨尺寸在150 μ m和400 μm之间。当用于从12天大的小鼠胚胎获得的PA数据时，DAS + SCF处理改善了神经血管的可视化。
This paper presents an adaptive synthetic-focusing scheme that, when applied to photoacoustic (PA) data acquired using an annular array, improves focusing across a greater imaging depth and enhances spatial resolution. The imaging system was based on a 40-MHz, 5-element, annular-array transducer with a focal length of 12 mm and an 800-μm diameter hole through its central element to facilitate coaxial delivery of 532-nm laser. The transducer was raster-scanned to facilitate 3D acquisition of co-registered ultrasound and PA image data. Three synthetic-focusing schemes were compared for obtaining PA A-lines for each scan location: delay-and-sum (DAS), DAS weighted with a coherence factor (DAS + CF), and DAS weighted with a sign-coherence factor (DAS + SCF). Bench-top experiments that used an 80-μm hair were performed to assess the enhancement provided by the two coherence-based schemes. Both coherence-based schemes increased the signal-to-noise ratio by approximately 10 dB. When processed using the DAS-only scheme, the lateral dimension of the hair in a PA image with 20 dB dynamic range was between 300 μm and 1 mm for imaging depth ranging from 8 to 20 mm. In comparison, the DAS + CF scheme resulted in a lateral dimension of 200 to 450 μm over the same range. The DAS + SCF synthetic focusing further improved the smallest-resolvable dimension, which was between 150 and 400 μm over the same range of imaging depth. When used on PA data obtained from a 12-day-old mouse embryo, the DAS + SCF processing improved visualization of neurovasculature.
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DOI：
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发表时间：
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期刊：
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影响因子：
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作者：
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