Association between Growth Differentiation Factor-15 (GDF-15) Serum Levels, Anorexia and Low Muscle Mass among Cancer Patients.
Association between Growth Differentiation Factor-15 (GDF-15) Serum Levels, Anorexia and Low Muscle Mass among Cancer Patients.
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DOI：
10.3390/cancers13010099
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发表时间：
2020-12-31
期刊：
影响因子：
5.2
通讯作者：
Muscaritoli M
中科院分区：
文献类型：
--
作者：
Molfino A;Amabile MI;Imbimbo G;Rizzo V;Pediconi F;Catalano C;Emiliani A;Belli R;Ramaccini C;Parisi C;Nigri G;Muscaritoli M
在我们的研究中，新的炎症细胞因子生长分化因子-15（GDF-15）已被发现在胃肠癌和肺癌患者中升高，并与厌食症相关。发现胃肠道癌患者比肺癌患者更易受感染（基于FAACT评分），并显示出更高的GDF-15血清水平。我们还通过CT扫描评估了患者的肌肉状况。在具有低肌肉质量的癌症患者与具有中等/高肌肉量的癌症患者之间以及在具有体重减轻的患者与具有稳定体重的患者之间没有发现GDF-15水平的差异。基于我们的观察，我们证实了GDF-15在癌症厌食症发病机制中的作用，尽管这种细胞因子在癌症中的作用机制还应进一步揭示其在肌肉变化中的潜在参与。癌症厌食症的病理生理学是复杂的，并且血清生物标志物，包括生长和分化因子（GDF），可以被调节。我们探索了GDF-15血清水平与厌食症之间的关联，其次是与癌症患者的低肌肉质量和体重减轻之间的关联。我们考虑了胃肠道和肺癌患者（CP）和BMI匹配的健康对照。FAACT问卷被用来诊断厌食症，我们通过CT扫描计算L3-SMI来评估低肌肉含量，将其截止值设置为最低的三分位数。通过ELISA评估GDF-15血清水平。我们招募了59名CP和30名对照;在CP中，25名受胃肠道癌影响，34名受肺癌影响。36%的CP存在厌食症。与肺CP相比，胃肠道CP导致的死亡率更高（p = 0.0067）。33.9%的CP存在低肌肉质量，胃肠道中的L3-SMI低于肺CP（p = 0.049）。CP中的GDF-15水平高于对照组（p = 0.00016），以及在前列腺癌中高于非前列腺癌CP（p = 0.005）和对照组（p < 0.0001）。胃肠道CP显示出比肺CP更高的GDF-15水平（p = 0.0004）。低肌肉量CP与中/高肌肉量CP之间以及体重减轻患者与体重稳定患者之间的GDF-15无差异。我们的数据支持GDF-15参与癌症厌食症的发病机制。GDF-15在癌症中的作用机制还应进一步阐明肌肉组织的变化。
In our study, the novel inflammatory cytokine Growth Differentiation Factor-15 (GDF-15) has been found elevated in patients with gastrointestinal and lung cancer and associated with anorexia. Patients with gastrointestinal cancer were found more anorexic (based on the FAACT score) and showed higher GDF-15 serum levels than patients with lung cancer. We also evaluated the muscularity status of the patients by CT scan. No difference was found in GDF-15 levels between cancer patients with low muscle mass vs. those with moderate/high muscularity and between patients with body weight loss vs. those with stable weight. Based on our observations, we confirm the role of GDF-15 in the pathogenesis of anorexia in cancer, although the mechanisms of action of this cytokine in cancer should be further unveiled also regarding its potential involvement in changes in muscularity. The pathophysiology of cancer anorexia is complex and serum biomarkers, including growth and differentiation factor(s) (GDF), may be modulated. We explored the association(s) between GDF-15 serum levels and anorexia and, secondarily, with low muscle mass and body weight loss in cancer patients. We considered gastrointestinal and lung cancer patients (CP) and healthy BMI-matched controls. The FAACT-questionnaire was administered to diagnose anorexia and we calculated the L3-SMI by CT scan to assess low muscularity, setting their cutoff values at the lowest tertile. GDF-15 serum levels were assessed by ELISA. We enrolled 59 CP and 30 controls; among CP, 25 were affected by gastrointestinal and 34 by lung cancer. Anorexia was present in 36% of CP. Gastrointestinal CP resulted more anorexic compared to lung CP (p = 0.0067). Low muscle mass was present in 33.9% of CP and L3-SMI was lower in gastrointestinal compared to lung CP (p = 0.049). The GDF-15 levels were higher in CP vs. controls (p = 0.00016), as well as in anorexic vs. non-anorexic CP (p = 0.005) and vs. controls (p < 0.0001). Gastrointestinal CP showed higher GDF-15 levels vs. lung CP (p = 0.0004). No difference was found in GDF-15 between CP with low muscle mass and those with moderate/high muscularity and between patients with body weight loss and those with stable weight. Our data support the involvement of GDF-15 in the pathogenesis of cancer anorexia. The mechanisms of action of GDF-15 in cancer should be further clarified also regarding the changes in muscularity.
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影响因子：
8.8
作者：
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影响因子：
5.4
作者：
McGrath ER;Himali JJ;Levy D;Conner SC;DeCarli C;Pase MP;Ninomiya T;Ohara T;Courchesne P;Satizabal CL;Vasan RS;Beiser AS;Seshadri S
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通讯作者：
Laviano, Alessandro
影响因子：
2.4
作者：
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通讯作者：
Rossi Fanelli, Filippo
DOI：
10.1097/spc.0b013e32833e4aa5
发表时间：
2010-12-01
影响因子：
2.1
作者：
Molfino, Alessio;Laviano, Alessandro;Rossi Fanelli, Filippo
通讯作者：
Rossi Fanelli, Filippo