A student team in a University of Michigan biomedical engineering design course constructs a microfluidic bioreactor for studies of zebrafish development.
A student team in a University of Michigan biomedical engineering design course constructs a microfluidic bioreactor for studies of zebrafish development.
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DOI：
10.1089/zeb.2008.0572
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发表时间：
2009-06
期刊：
影响因子：
2
通讯作者：
Barald KF
中科院分区：
文献类型：
--
作者：
Shen YC;Li D;Al-Shoaibi A;Bersano-Begey T;Chen H;Ali S;Flak B;Perrin C;Winslow M;Shah H;Ramamurthy P;Schmedlen RH;Takayama S;Barald KF
斑马鱼是一个有价值的模型，用于教学发育，分子和细胞生物学;水生科学;比较解剖学;生理学;和遗传学。在这里，我们证明，斑马鱼提供了一个很好的模型系统，教工程原理。一个由七名成员组成的生物医学工程本科团队设计，建造和测试了一个斑马鱼微流体生物反应器，该生物反应器应用微流体技术（一种新兴的工程技术）来研究斑马鱼发育。在学期中，学生学习了工程和生物学实验设计，芯片微加工，数学建模，斑马鱼饲养，发育生物学原理，流体动力学，显微镜和基本分子生物学理论和技术。该小组努力最大限度地发挥每个人的贡献，每周提交书面和口头报告。两名博士后研究员，一名研究生和三名教师协调和指导团队在工程，分子和发育生物学技能的最佳组合。学生们展示了两张海报，其中一张是在威斯康星州的麦迪逊举行的斑马鱼会议上（2008年6月）。
The zebrafish is a valuable model for teaching developmental, molecular, and cell biology; aquatic sciences; comparative anatomy; physiology; and genetics. Here we demonstrate that zebrafish provide an excellent model system to teach engineering principles. A seven-member undergraduate team in a biomedical engineering class designed, built, and tested a zebrafish microfluidic bioreactor applying microfluidics, an emerging engineering technology, to study zebrafish development. During the semester, students learned engineering and biology experimental design, chip microfabrication, mathematical modeling, zebrafish husbandry, principles of developmental biology, fluid dynamics, microscopy, and basic molecular biology theory and techniques. The team worked to maximize each person's contribution and presented weekly written and oral reports. Two postdoctoral fellows, a graduate student, and three faculty instructors coordinated and directed the team in an optimal blending of engineering, molecular, and developmental biology skill sets. The students presented two posters, including one at the Zebrafish meetings in Madison, Wisconsin (June 2008).
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影响因子：
7.4
作者：
Heo, Yun Seok;Cabrera, Lourdes M.;Takayama, Shuichi
通讯作者：
Takayama, Shuichi
影响因子：
2.5
作者：
Gerlach-Bank, LM;Ellis, AD;Barald, KF
通讯作者：
Barald, KF
DOI：
10.1088/0960-1317/18/6/067001
发表时间：
2008-06-01
影响因子：
2.3
作者：
Eddings, Mark A.;Johnson, Michael A.;Gale, Bruce K.
通讯作者：
Gale, Bruce K.
影响因子：
2.9
作者：
Ito, Kanako;Yoshiura, Yasutoshl;Nakanishi, Teruyuki
通讯作者：
Nakanishi, Teruyuki
影响因子：
2.5
作者：
KIMMEL, CB;BALLARD, WW;SCHILLING, TF
通讯作者：
SCHILLING, TF