Phenotypic and Functional Characterization of Circulatory, Splenic, and Hepatic NK Cells in Simian Immunodeficiency Virus-Controlling Macaques.
Phenotypic and Functional Characterization of Circulatory, Splenic, and Hepatic NK Cells in Simian Immunodeficiency Virus-Controlling Macaques.
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DOI：
10.4049/jimmunol.1700586
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发表时间：
2017-11-01
期刊：
影响因子：
--
通讯作者：
Robert-Guroff M
中科院分区：
文献类型：
--
作者：
Vargas-Inchaustegui DA;Helmold Hait S;Chung HK;Narola J;Hoang T;Robert-Guroff M
NK细胞是免疫系统的关键组成部分，因为它们具有快速反应潜力和介导细胞毒性和免疫调节功能的能力。此外，NK细胞最近已被证明在体内持续很长时间，并具有建立免疫记忆的能力。在本研究中，我们研究了循环和组织驻留NK细胞的表型和功能，在一个独特的队列SIV控制恒河猴，保持低至不可检测的病毒血症水平在慢性感染阶段。通过将这些猕猴的NK反应与SIV非控制和未感染猕猴中观察到的NK反应进行比较，我们的目标是鉴定与疾病控制相关的NK亚群的标记物和活性。我们在这里表明，三组猕猴的NK细胞之间的最大差异观察组织驻留细胞。虽然SIV感染导致NK细胞功能障碍，但双阴性NK细胞和表达CXCR 3、NKG 2D和IL-18 R α的NK细胞与病毒血症控制相关，抗体依赖性细胞毒性功能也是如此。我们的研究结果提出了几个新的治疗干预的目标。
NK cells are key components of the immune system due to their rapid response potential and their ability to mediate cytotoxic and immunomodulatory functions. Additionally, NK cells have recently been shown to persist for long periods in vivo and to have the capacity to establish immunologic memory. In the present study we studied the phenotype and function of circulatory and tissue-resident NK cells in a unique cohort of SIV controlling rhesus macaques that maintained low to undetectable levels of viremia in the chronic phase of infection. By contrasting NK responses of these macaques with those observed in SIV non-controlling and uninfected macaques we aimed to identify markers and activities of NK subpopulations associated with disease control. We show here that most differences among NK cells of the three groups of macaques were observed in tissue-resident cells. While SIV infection resulted in NK cell dysfunction, double negative NK cells, and those expressing CXCR3, NKG2D, and IL-18Rα were associated with viremia control, as was antibody-dependent cytotoxic function. Our results suggest several novel targets for therapeutic intervention.
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DOI：
10.4049/jimmunol.1303211
发表时间：
2014-05-15
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Hendricks DW;Balfour HH Jr;Dunmire SK;Schmeling DO;Hogquist KA;Lanier LL
通讯作者：
Lanier LL
影响因子：
8.7
作者：
Cooper MA;Yokoyama WM
通讯作者：
Yokoyama WM
影响因子：
16.8
作者：
Rydyznski CE;Waggoner SN
通讯作者：
Waggoner SN
影响因子：
4.4
作者：
Horowitz, Amir;Behrens, Ron H.;Riley, Eleanor M.
通讯作者：
Riley, Eleanor M.
影响因子：
1.5
作者：
Isitman, Gamze;Lisovsky, Irene;Bernard, Nicole F.
通讯作者：
Bernard, Nicole F.