Memory-like responses of natural killer cells.
Memory-like responses of natural killer cells.
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DOI：
10.1111/j.0105-2896.2010.00891.x
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发表时间：
2010-05
影响因子：
8.7
通讯作者：
Yokoyama WM
中科院分区：
文献类型：
--
作者：
Cooper MA;Yokoyama WM
自然杀伤 (NK) 细胞是淋巴细胞，能够产生细胞因子并在激活后杀死靶细胞。 NK细胞长期以来一直被归类为先天免疫系统的成员，因此被认为遵循先天免疫的“规则”，包括它们没有免疫记忆的原则，这一特性被认为严格限于适应性免疫。然而，最近的研究表明 NK 细胞有能力根据先前的激活来改变其行为。这种特性类似于适应性免疫记忆；然而，一些 NK 细胞记忆样功能并不严格依赖于抗原，并且可以在细胞因子刺激后得到证实。在这里，我们讨论最近的证据，表明 NK 细胞可以表现出免疫记忆特性，重点关注细胞因子非特异性诱导记忆样 NK 细胞的能力，并增强对再刺激的反应。
Natural killer (NK) cells are lymphocytes with the capacity to produce cytokines and kill target cells upon activation. NK cells have long been categorized as members of the innate immune system and as such have been thought to follow the ‘rules’ of innate immunity, including the principle that they have no immunologic memory, a property thought to be strictly limited to adaptive immunity. However, recent studies have suggested that NK cells have the capacity to alter their behavior based on prior activation. This property is analogous to adaptive immune memory; however, some NK cell memory-like functions are not strictly antigen-dependent and can be demonstrated following cytokine stimulation. Here we discuss the recent evidence that NK cells can exhibit properties of immunologic memory, focusing on the ability of cytokines to non-specifically induce memory-like NK cells with enhanced responses to restimulation.
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影响因子：
64.8
作者：
Cella, Marina;Fuchs, Anja;Vermi, William;Facchetti, Fabio;Otero, Karel;Lennerz, Jochen K. M.;Doherty, Jason M.;Mills, Jason C.;Colonna, Marco
通讯作者：
Colonna, Marco
影响因子：
56.9
作者：
Brown, MG;Dokun, AO;Yokoyama, WM
通讯作者：
Yokoyama, WM
影响因子：
30.5
作者：
Andrews, DM;Scalzo, AA;Degli-Esposti, MA
通讯作者：
Degli-Esposti, MA
影响因子：
4.4
作者：
Campbell, JJ;Qin, SX;Butcher, EC
通讯作者：
Butcher, EC
影响因子：
20.3
作者：
Beuneu, Helene;Deguine, Jacques;Bousso, Philippe
通讯作者：
Bousso, Philippe