Disagreement in F(ST) estimators: A case study from sex chromosomes.

Disagreement in F(ST) estimators: A case study from sex chromosomes.
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DOI:
10.1111/1755-0998.13210
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发表时间:
2020-11
影响因子:
7.7
通讯作者:
Vicoso B
Vicoso B
中科院分区:
生物学1区
文献类型:
--
作者:
Gammerdinger WJ;Toups MA;Vicoso B

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Sewall Wright开发了FST来描述种群分化,并且已经扩展到许多新的应用,包括检测同态性染色体。然而,在比较男性和女性时,对于X和Y染色体之间固定差异的F ST的预期估计值存在混淆。在这里,我们试图通过比较两种常见的F ST估计量来解决这种混乱,并解释为什么它们在应用于性染色体的情况时会产生不同的估计。我们发现,这种差异对于许多等位基因频率都是真实的,但X和Y染色体之间的固定差异是最极端的情况。为了避免额外的混乱,我们建议所有使用F ST的作者清楚地说明他们的工作使用的F ST的估计量。
Sewall Wright developed F ST for describing population differentiation and it has since been extended to many novel applications, including the detection of homomorphic sex chromosomes. However, there has been confusion regarding the expected estimate of F ST for a fixed difference between the X‐ and Y‐chromosome when comparing males and females. Here, we attempt to resolve this confusion by contrasting two common F ST estimators and explain why they yield different estimates when applied to the case of sex chromosomes. We show that this difference is true for many allele frequencies, but the situation characterized by fixed differences between the X‐ and Y‐chromosome is among the most extreme. To avoid additional confusion, we recommend that all authors using F ST clearly state which estimator of F ST their work uses.
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