Plasma cytokine profiles in systemic sclerosis: associations with autoantibody subsets and clinical manifestations.
Plasma cytokine profiles in systemic sclerosis: associations with autoantibody subsets and clinical manifestations.
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DOI：
10.1186/ar2821
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发表时间：
2009
影响因子：
4.9
通讯作者：
Agarwal SK
中科院分区：
文献类型：
--
作者：
Gourh P;Arnett FC;Assassi S;Tan FK;Huang M;Diekman L;Mayes MD;Reveille JD;Agarwal SK
系统性硬化症(SSC)(硬皮病)是一种复杂的自身免疫性疾病，临床表现为皮肤和内脏进行性纤维化。抗着丝粒抗体(ACAs)、抗拓扑异构酶抗体(ATA)和抗RNA聚合酶III抗体(ARAs)是三种相互排斥的SSC相关自身抗体，它们与不同的临床亚型相关，其特征是皮肤受累的程度和器官受累的类型。目前的报告试图确定根据这些与SSC相关的自身抗体亚群分组的SSC患者的血浆细胞因子谱是否不同。来自硬皮病家族登记处和德克萨斯大学风湿科的444名SSC患者和216名健康对照的血浆。根据ACAs、ATAs、ARAs存在与否(抗体阴性)对患者进行分类。用多重分析法检测13种细胞因子的水平。健康对照组男性血浆IL-2(P=0.008.0 1)、IL-5(P=0.0 1)和IL-8(P=0.0 1)水平均高于女性。此外，对照组IL-6(P=0.02)和IL-17(P=0.01)水平随年龄增长而升高。在调整了年龄和性别后，SSc患者循环中肿瘤坏死因子α(P<；0.0001)、IL-6(P<；0.0001)和干扰素γ(P=0.0001)水平较高，而IL-17(P=0.0005)和IL-23(P=0.014)水平较低。进一步的分析表明，病程也会影响这些细胞因子的分布。IL-6在ATA阳性和ARA阳性患者中升高，但在ACA阳性患者中不升高。IL-8仅在ATA阳性亚群中升高，而ATA阳性和ACA阳性亚群均升高干扰素γ和IL-10。IL-5仅在ACA阳性亚群中显著升高。最后，间质性肺病患者IL-6升高，肺动脉高压患者IL-6和IL-13升高。根据SSc相关自身抗体的存在，SSc患者的血浆细胞因子谱有所不同。SSC患者的血浆细胞因子谱也可能受到病程和内脏器官受累模式的影响。
Systemic sclerosis (SSc) (scleroderma) is a complex autoimmune disease that clinically manifests as progressive fibrosis of the skin and internal organs. Anti-centromere antibodies (ACAs), anti-topoisomerase antibodies (ATAs), and anti-RNA polymerase III antibodies (ARAs) are three mutually exclusive SSc-associated autoantibodies that correlate with distinct clinical subsets characterized by extent of cutaneous involvement and pattern of organ involvement. The current report sought to determine whether plasma cytokine profiles differ in SSc patients grouped according to these SSc-associated autoantibody subsets. Plasma from 444 SSc patients and 216 healthy controls was obtained from the Scleroderma Family Registry and University of Texas Rheumatology Division. Patients were classified according to the presence of ACAs, ATAs, ARAs, or none of the above (antibody-negative). Levels of 13 cytokines were determined using multiplex assays. Compared with females, healthy control males had higher plasma levels of IL-2 (P = 0.008), IL-5 (P = 0.01) and IL-8 (P = 0.01). In addition, in controls, IL-6 (P = 0.02) and IL-17 (P = 0.01) levels increased with advancing age. After adjusting for age and gender, SSc patients had higher circulating levels of TNFα (P < 0.0001), IL-6 (P < 0.0001), and IFNγ (P = 0.05) and lower IL-17 (P = 0.0005) and IL-23 (P = 0.014). Additional analyses demonstrated that disease duration also influenced these cytokine profiles. IL-6 was elevated in ATA-positive and ARA-positive patients, but not in ACA-positive patients. IL-8 was uniquely increased in the ATA-positive subset while both ATA-positive and ACA-positive subsets had elevated IFNγ and IL-10. IL-5 was only significantly increased in the ACA-positive subset. Lastly, patients with interstitial lung disease had elevated IL-6 and patients with pulmonary hypertension had elevated IL-6 and IL-13. Plasma cytokine profiles differ in SSc patients based on the presence of SSc-associated autoantibodies. Plasma cytokine profiles in SSc patients may also be affected by disease duration and the pattern of internal organ involvement.
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影响因子：
64.8
作者：
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通讯作者：
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