Proprioceptive coupling within motor neurons drives C. elegans forward locomotion.
Proprioceptive coupling within motor neurons drives C. elegans forward locomotion.
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DOI：
10.1016/j.neuron.2012.08.039
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发表时间：
2012-11-21
期刊：
影响因子：
16.2
通讯作者：
Samuel AD
中科院分区：
文献类型：
--
作者：
Wen Q;Po MD;Hulme E;Chen S;Liu X;Kwok SW;Gershow M;Leifer AM;Butler V;Fang-Yen C;Kawano T;Schafer WR;Whitesides G;Wyart M;Chklovskii DB;Zhen M;Samuel AD
运动需要动物全身协调的运动活动。在脊椎动物和无脊椎动物中，耦合的中央模式发生器（CPG）链通常被诱发来解释局部节律行为。In C. elegans，我们报告说，本体感觉内的运动回路负责传播和协调节奏波动波从头部到尾部在向前运动。邻近身体区域之间的本体感受耦合将头部附近发起的有节奏运动转换成由反射链驱动沿着身体的弯曲波。利用光遗传学和钙离子成像技术操纵和监测运动C.在微流控装置中，我们发现B型胆碱能运动神经元传递本体感受信号。In C.在一种特殊类型的运动神经元内运行的感觉运动反馈回路既驱动又组织身体运动。
Locomotion requires coordinated motor activity throughout an animal’s body. In both vertebrates and invertebrates, chains of coupled Central Pattern Generators (CPGs) are commonly evoked to explain local rhythmic behaviors. In C. elegans, we report that proprioception within the motor circuit is responsible for propagating and coordinating rhythmic undulatory waves from head to tail during forward movement. Proprioceptive coupling between adjacent body regions transduces rhythmic movement initiated near the head into bending waves driven along the body by a chain of reflexes. Using optogenetics and calcium imaging to manipulate and monitor motor circuit activity of moving C. elegans held in microfluidic devices, we found that the B-type cholinergic motor neurons transduce the proprioceptive signal. In C. elegans, a sensorimotor feedback loop operating within a specific type of motor neuron both drives and organizes body movement.
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