Association Between 12 Polymorphisms of VEGF/Hypoxia/Angiogenesis Pathway Genes and Risk of Urogenital Carcinomas: A Meta-Analysis Based on Case-Control Studies.
Association Between 12 Polymorphisms of VEGF/Hypoxia/Angiogenesis Pathway Genes and Risk of Urogenital Carcinomas: A Meta-Analysis Based on Case-Control Studies.
复制标题
VEGF/缺氧/血管生成通路基因的 12 个多态性与泌尿生殖道癌风险的关联：基于病例对照研究的荟萃分析
DOI：
10.3389/fphys.2018.00715
复制
发表时间：
2018
影响因子：
4
通讯作者：
Zu XB
中科院分区：
文献类型：
--
作者：
Chen JB;Zhang M;Cui Y;Liu PH;Qi YW;Li C;Cheng X;Ren WB;Li QQ;Liu LF;Chen MF;Chen HQ;Zu XB
目的：既往研究表明 VEGF/缺氧/血管生成通路基因多态性与泌尿生殖癌风险之间存在潜在关联，但结果存在争议且尚无定论。在这里，我们进行了深入的荟萃分析，以研究 VEGF/缺氧/血管生成相关基因的多态性与泌尿生殖癌风险之间的精确关联。方法：我们检索了 PubMed、Web of Science、EMBASE 和 Cochrane 图书馆，以确定所有符合条件的出版物。计算与 95% 置信区间 (CI) 相对应的合并比值比 (OR) 以评估它们的关联。进行亚组分析以进一步确定这种关系并调查异质性的来源。结果：最终共纳入96项符合纳入标准的病例对照研究，共纳入4个VEGF/缺氧/血管生成相关基因的12个多态性。汇总结果显示，eNOS-rs2070744 多态性分别导致等位基因、纯合子和隐性模型中泌尿生殖癌的总体风险显着增加。此外，eNOS-Intron 4a/b VNTR 多态性被发现与隐性模型中泌尿生殖癌风险增加有关。在等位基因、杂合子、显性、纯合子和隐性模型中，VEGF-rs699947 多态性也被发现会增加肾细胞癌 (RCC) 的风险。结论：综上所述，eNOS-rs2070744 和 eNOS-Intron 4a/b VNTR 多态性是泌尿生殖癌的危险因素。 VEGF-rs699947 多态性也被确定为肾癌风险增加的因素。
Objective: Previous studies indicated potential associations between polymorphisms in genes of VEGF/hypoxia/angiogenesis pathway and risk of urogenital carcinomas However, the results were controversial and inconclusive. Here, we conducted an in-depth meta-analysis to investigate the precise associations between polymorphisms in VEGF/hypoxia/angiogenesis related genes and risk of urogenital carcinomas. Methods: We searched PubMed, Web of Science, EMBASE, and Cochrane Library to identify all eligible publications. Pooled odds ratios (ORs) corresponding with the 95% confidence intervals (CIs) were calculated to evaluate their associations. Subgroup analysis was conducted to further ascertain such relationship and investigate sources of heterogeneity. Results: In the end, a total of 96 case-control studies fulfilled the inclusion criteria were enrolled for 12 polymorphisms in 4 VEGF/hypoxia/angiogenesis related genes. The pooled results showed eNOS-rs2070744 polymorphism conferred a significantly increased overall risk of urogenital carcinomas in allele, homozygote, and recessive models, respectively. In addition, eNOS-Intron 4a/b VNTR polymorphism was identified related to an increased risk of urogenital carcinomas in recessive model. And VEGF-rs699947 polymorphism was also identified an increased risk of renal cell carcinoma (RCC) in allelic, heterozygote, dominant, homozygote, and recessive models. Conclusion: To conclude, eNOS-rs2070744 and eNOS-Intron 4a/b VNTR polymorphisms are risk factors for urogenital carcinomas. VEGF-rs699947 polymorphism was also identified as an increased risk factor for renal carcinoma.
登录
查看更多内容
DOI：
10.1007/s00432-016-2137-0
发表时间：
2016-06-01
影响因子：
3.6
作者：
Dornbusch, Juana;Walter, Martina;Fuessel, Susanne
通讯作者：
Fuessel, Susanne
DOI：
10.1016/j.urolonc.2010.08.028
发表时间：
2012-09-01
影响因子：
2.7
作者：
Alberto Henriquez-Hernandez, Luis;Navarro, Patricio;Valeron, Pilar F.
通讯作者：
Valeron, Pilar F.
影响因子：
0.6
作者：
Diler, S. B.;Oden, A.
通讯作者：
Oden, A.
影响因子：
3.6
作者：
Chau, CH;Permenter, MG;Figg, WD
通讯作者：
Figg, WD
影响因子：
0.4
作者：
Ceylan, G. G.;Ceylan, C.;Ozturk, E.
通讯作者：
Ozturk, E.