NetworKIN: a resource for exploring cellular phosphorylation networks.
NetworKIN: a resource for exploring cellular phosphorylation networks.
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DOI：
10.1093/nar/gkm902
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发表时间：
2008-01
影响因子：
14.9
通讯作者：
Pawson T
中科院分区：
文献类型：
--
作者：
Linding R;Jensen LJ;Pasculescu A;Olhovsky M;Colwill K;Bork P;Yaffe MB;Pawson T
Protein kinases control cellular responses by phosphorylating specific substrates. Recent proteome-wide mapping of protein phosphorylation sites by mass spectrometry has discovered thousands of in vivo sites. Systematically assigning all 518 human kinases to all these sites is a challenging problem. The NetworKIN database (http://networkin.info) integrates consensus substrate motifs with context modelling for improved prediction of cellular kinase–substrate relations. Based on the latest human phosphoproteome from the Phospho.ELM and PhosphoSite databases, the resource offers insight into phosphorylation-modulated interaction networks. Here, we describe how NetworKIN can be used for both global and targeted molecular studies. Via the web interface users can query the database of precomputed kinase–substrate relations or obtain predictions on novel phosphoproteins. The database currently contains a predicted phosphorylation network with 20 224 site-specific interactions involving 3978 phosphoproteins and 73 human kinases from 20 families.
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影响因子：
14.9
作者：
von Mering C;Jensen LJ;Kuhn M;Chaffron S;Doerks T;Krüger B;Snel B;Bork P
通讯作者：
Bork P
影响因子：
4.4
作者：
Hjerrild, M;Stensballe, A;Gammeltoft, S
通讯作者：
Gammeltoft, S
影响因子：
14.9
作者：
Obenauer, JC;Cantley, LC;Yaffe, MB
通讯作者：
Yaffe, MB
影响因子：
14.9
作者：
Wong YH;Lee TY;Liang HK;Huang CM;Wang TY;Yang YH;Chu CH;Huang HD;Ko MT;Hwang JK
通讯作者：
Hwang JK
影响因子：
64.5
作者：
Linding, Rune;Jensen, Lars Juhl;Pawson, Tony
通讯作者：
Pawson, Tony