Nur transcription factors in stress and addiction.
Nur transcription factors in stress and addiction.
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DOI：
10.3389/fnmol.2013.00044
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发表时间：
2013-12-02
影响因子：
4.8
通讯作者：
Andrés ME
中科院分区：
文献类型：
--
作者：
Campos-Melo D;Galleguillos D;Sánchez N;Gysling K;Andrés ME
Nur转录因子Nur77(NGFI-B，NR4A1)、Nurr1(NR4A2)和NOR-1(NR4A3)是核受体超家族的孤儿成员。这些转录因子是即刻早期基因的产物，它们的表达在中枢神经系统中被几种类型的刺激快速而短暂地诱导。Nur因子存在于下丘脑-垂体-肾上腺(HPA)轴上，在应激反应中显著诱导。滥用和应激药物也会诱导Nur因子在大脑动机/奖励环路的核中表达，表明它们参与了药物成瘾过程和非下丘脑对应激的反应。由于基因表达的重新编程和神经元功能的持久变化，反复使用成瘾药物和慢性应激会导致大脑动机/奖励回路的长期失调。在这里，我们回顾了支持Nur转录因子在慢性应激和成瘾涉及的神经元回路失调的分子基础上的关键角色的数据。
The Nur transcription factors Nur77 (NGFI-B, NR4A1), Nurr1 (NR4A2), and Nor-1 (NR4A3) are a sub-family of orphan members of the nuclear receptor superfamily. These transcription factors are products of immediate early genes, whose expression is rapidly and transiently induced in the central nervous system by several types of stimuli. Nur factors are present throughout the hypothalamus-pituitary-adrenal (HPA) axis where are prominently induced in response to stress. Drugs of abuse and stress also induce the expression of Nur factors in nuclei of the motivation/reward circuit of the brain, indicating their participation in the process of drug addiction and in non-hypothalamic responses to stress. Repeated use of addictive drugs and chronic stress induce long-lasting dysregulation of the brain motivation/reward circuit due to reprogramming of gene expression and enduring alterations in neuronal function. Here, we review the data supporting that Nur transcription factors are key players in the molecular basis of the dysregulation of neuronal circuits involved in chronic stress and addiction.
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作者：
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