Physical activity moderates the association between white matter hyperintensity burden and cognitive change.
Physical activity moderates the association between white matter hyperintensity burden and cognitive change.
复制标题
DOI：
10.3389/fnagi.2022.945645
复制
发表时间：
2022
影响因子：
4.8
通讯作者：
中科院分区：
文献类型：
--
作者：
更多的体力活动(PA)可以延缓认知能力的下降，但潜在的机制尚不清楚。白质高强度(WMH)负荷是关键的大脑病理之一，已被证明可以预测老年人认知能力下降的速度更快。一种可能的途径是，PA可能通过减轻大脑疾病(如WMH)对认知变化的有害影响来帮助维持认知。这项研究旨在检验PA是否缓和了WMH负担和认知变化之间的联系。这项以人群为基础的纵向研究包括198名20-80岁的无痴呆症成年人。休闲体力活动(LTPA)采用自填式问卷进行评估。职业性体力活动(OPA)是衡量每个工作的体力需求的一个因素分数。总体力活动(TPA)被操作为LTPA和OPA的z-分数的平均值。结果变量包括全球认知和四种参考能力(流畅推理、处理速度、记忆和词汇)的5年变化。多变量线性回归模型被用来评估PA对白质高信号与认知变化之间的关系的调节作用，调整了年龄、性别、教育程度和基线认知。在大约5年的时间里，全球认知(p<；0.001)、推理(p<；0.001)、速度(p<；0.001)和记忆力(p<；0.001)分数下降，词汇量(p<；0.001)增加。WMH负荷越大，总体认知(Spearman‘s Rho=-0.229，p=0.001)、推理(Rho=-0.402，p<；0.001)和速度(Rho=-0.319，p<；0.001)下降越多，词汇量增加(Rho=-0.316，p<；0.001)越少。更大的TPA减弱了WMH负担与推理(βTPA^*WMH=0.029，95%CI=0.006-0.052，p=0.013)、速度(βTPA^*WMH=0.035，95%CI=-0.004-0.065，p=0.028)和词汇量(βTPA^*WMH=0.034，95%CI=0.004-0.065p=0.029)之间的关系。OPA似乎对WMH负荷与认知变化之间的关系起到了较强的调节作用。体力活动可能有助于在面对WMH负担时保持推理、速度和词汇能力。PA的认知储备潜力值得进一步研究。
Greater physical activity (PA) could delay cognitive decline, yet the underlying mechanisms remain unclear. White matter hyperintensity (WMH) burden is one of the key brain pathologies that have been shown to predict faster cognitive decline at a late age. One possible pathway is that PA may help maintain cognition by mitigating the detrimental effects of brain pathologies, like WMH, on cognitive change. This study aims to examine whether PA moderates the association between WMH burden and cognitive change. This population-based longitudinal study included 198 dementia-free adults aged 20–80 years. Leisure-time physical activity (LTPA) was assessed by a self-reported questionnaire. Occupational physical activity (OPA) was a factor score measuring the physical demands of each job. Total physical activity (TPA) was operationalized as the average of z-scores of LTPA and OPA. Outcome variables included 5-year changes in global cognition and in four reference abilities (fluid reasoning, processing speed, memory, and vocabulary). Multivariable linear regression models were used to estimate the moderation effect of PA on the association between white matter hyperintensities and cognitive change, adjusting for age, sex, education, and baseline cognition. Over approximately 5 years, global cognition (p < 0.001), reasoning (p < 0.001), speed (p < 0.001), and memory (p < 0.05) scores declined, and vocabulary (p < 0.001) increased. Higher WMH burden was correlated with more decline in global cognition (Spearman’s rho = –0.229, p = 0.001), reasoning (rho = –0.402, p < 0.001), and speed (rho = –0.319, p < 0.001), and less increase in vocabulary (rho = –0.316, p < 0.001). Greater TPA attenuated the association between WMH burden and changes in reasoning (βTPA^*WMH = 0.029, 95% CI = 0.006–0.052, p = 0.013), speed (βTPA^*WMH = 0.035, 95% CI = –0.004–0.065, p = 0.028), and vocabulary (βTPA^*WMH = 0.034, 95% CI = 0.004–0.065, p = 0.029). OPA seemed to be the factor that exerted a stronger moderation on the relationship between WMH burden and cognitive change. Physical activity may help maintain reasoning, speed, and vocabulary abilities in face of WMH burden. The cognitive reserve potential of PA warrants further examination.
登录
查看更多内容
影响因子：
4
作者：
Godin, Ophelia;Tzourio, Christophe;Dufouil, Carole
通讯作者：
Dufouil, Carole
影响因子：
3.6
作者：
Carvalho A;Rea IM;Parimon T;Cusack BJ
通讯作者：
Cusack BJ
影响因子：
2.8
作者：
Ben-David, Boaz M.;Tse, Vania Y. Y.;Schneider, Bruce A.
通讯作者：
Schneider, Bruce A.
影响因子：
4
作者：
Casaletto, Kaitlin B.;Renteria, Miguel Arce;Zahodne, Laura B.
通讯作者：
Zahodne, Laura B.
DOI：
10.1212/nxi.0000000000000521
发表时间：
2019-01-01
影响因子：
8.8
作者：
Gu, Yian;Gutierrez, Jose;Mayeux, Richard
通讯作者：
Mayeux, Richard