Development of a core outcome set for research and audit studies in reconstructive breast surgery.
Development of a core outcome set for research and audit studies in reconstructive breast surgery.
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DOI：
10.1002/bjs.9883
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发表时间：
2015-10
影响因子：
9.6
通讯作者：
Blazeby, J. M.
中科院分区：
文献类型：
--
作者：
Potter, S.;Holcombe, C.;Ward, J. A.;Blazeby, J. M.
如果研究要指导决策并为政策提供信息，则适当的结果选择至关重要。然而，乳房再造手术的临床、美容和患者报告结局的系统性综述显示出显著的异质性，并且无法比较或合并个体研究的结果。采用一套核心成果可能会改善这种情况。BRAVO研究为乳房再造手术制定了核心结局集。从系统评价和利益相关者访谈中确定的一长串结果被用于为问卷调查提供信息。关键利益相关者定义为参与乳房重建手术决策的个人，包括患者、乳房和整形外科医生、专科护士和心理学家，有目的地抽样并发送问卷（第1轮）。这要求他们在9分制的李克特量表上对每个结局的重要性进行评分，从1（不重要）到9（非常重要）。计算了将每个项目评为非常重要（7-9分）的答复者比例。在第二轮调查问卷（第二轮）中向参与者反馈了这一点。受访者被要求根据收到的反馈重新确定成果的优先次序。在协商一致会议上讨论了第二轮之后被认为非常重要的项目，并商定了一套核心成果。共有148个项目被合并为六个类别中的34个领域。大约303名参与者（51.4%）（434名患者中的215名（49.5%）; 156名专业人员中的88名（56.4%））完成并返回了第一轮问卷，259名（85.5%）在第二轮中重新确定了结果的优先顺序。根据调查表的分数，15个项目被排除在外，19个项目被带到协商一致会议，在协商一致会议上商定了一套核心成果，其中包括11项关键成果。BRAVO研究使用了强大的共识方法来制定乳房再造手术的核心结局集。重建社区的广泛采用将提高效果研究中结果评估的质量。未来的工作将评估如何最好地衡量这些关键成果。未来学习的指南针
Appropriate outcome selection is essential if research is to guide decision‐making and inform policy. Systematic reviews of the clinical, cosmetic and patient‐reported outcomes of reconstructive breast surgery, however, have demonstrated marked heterogeneity, and results from individual studies cannot be compared or combined. Use of a core outcome set may improve the situation. The BRAVO study developed a core outcome set for reconstructive breast surgery. A long list of outcomes identified from systematic reviews and stakeholder interviews was used to inform a questionnaire survey. Key stakeholders defined as individuals involved in decision‐making for reconstructive breast surgery, including patients, breast and plastic surgeons, specialist nurses and psychologists, were sampled purposively and sent the questionnaire (round 1). This asked them to rate the importance of each outcome on a 9‐point Likert scale from 1 (not important) to 9 (extremely important). The proportion of respondents rating each item as very important (score 7–9) was calculated. This was fed back to participants in a second questionnaire (round 2). Respondents were asked to reprioritize outcomes based on the feedback received. Items considered very important after round 2 were discussed at consensus meetings, where the core outcome set was agreed. A total of 148 items were combined into 34 domains within six categories. Some 303 participants (51·4 per cent) (215 (49·5 per cent) of 434 patients; 88 (56·4 per cent) of 156 professionals) completed and returned the round 1 questionnaire, and 259 (85·5 per cent) reprioritized outcomes in round 2. Fifteen items were excluded based on questionnaire scores and 19 were carried forward to the consensus meetings, where a core outcome set containing 11 key outcomes was agreed. The BRAVO study has used robust consensus methodology to develop a core outcome set for reconstructive breast surgery. Widespread adoption by the reconstructive community will improve the quality of outcome assessment in effectiveness studies. Future work will evaluate how these key outcomes should best be measured. A compass for future studies
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影响因子：
3.7
作者：
Gargon E;Gurung B;Medley N;Altman DG;Blazeby JM;Clarke M;Williamson PR
通讯作者：
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影响因子：
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通讯作者：
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