Functional reorganization of motor and limbic circuits after exercise training in a rat model of bilateral parkinsonism.
Functional reorganization of motor and limbic circuits after exercise training in a rat model of bilateral parkinsonism.
复制标题
DOI：
10.1371/journal.pone.0080058
复制
发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Holschneider DP
中科院分区：
文献类型：
--
作者：
Wang Z;Myers KG;Guo Y;Ocampo MA;Pang RD;Jakowec MW;Holschneider DP
运动训练广泛应用于帕金森病（PD）的神经康复。然而，关于长期有氧运动后受损大脑的功能重组却知之甚少。我们研究了为期4周的强迫跑轮运动在多巴胺能传入阻滞（双侧背侧纹状体6-羟基多巴胺损伤）大鼠模型中的作用。训练一周后，使用[14 C]-碘安替比林放射自显影术绘制踏车行走或休息时的脑灌注图。局部脑血流相关组织放射性（rCBF）进行了分析，在三维重建的大脑统计参数映射。在非运动大鼠中，病变导致持续的运动缺陷。与假损伤大鼠相比，损伤大鼠在行走过程中表现出改变的功能性脑激活，包括：1。纹状体和运动皮质的低活化; 2.基底节-丘脑皮质回路中非病变区域的过度激活; 3.红核、上级丘和躯体感觉皮层的功能性募集; 4.丘脑腹外侧区、小脑蚓部和深部核团的过度激活，提示小脑-丘脑皮质回路的募集; 5.边缘区（杏仁核、海马、腹侧纹状体、隔膜、中缝、海马）的过度激活。这些发现与PD患者报告的影像学结果具有显著相似性。运动逐步改善运动缺陷损伤大鼠，同时增加激活背侧纹状体和喙部次级运动皮层，衰减充血的小脑齿状回，并引发参与小脑-丘脑皮层回路的区域的功能重组。损伤和运动都增加了中脑边缘区（杏仁核、海马、腹侧纹状体、背侧被盖神经，腹侧苍白球），以及在相关的中脑边缘区（隔膜，缝，腹侧）。运动，而不是损伤，导致内侧前额叶皮层（扣带，边缘前，边缘下）的rCBF下降。我们在这个PD大鼠模型中的结果独特地突出了运动和边缘回路在病变和长期有氧运动后的功能重组的广度，并为理解基于运动的神经康复的神经基质提供了一个框架。
Exercise training is widely used for neurorehabilitation of Parkinson’s disease (PD). However, little is known about the functional reorganization of the injured brain after long-term aerobic exercise. We examined the effects of 4 weeks of forced running wheel exercise in a rat model of dopaminergic deafferentation (bilateral, dorsal striatal 6-hydroxydopamine lesions). One week after training, cerebral perfusion was mapped during treadmill walking or at rest using [14C]-iodoantipyrine autoradiography. Regional cerebral blood flow-related tissue radioactivity (rCBF) was analyzed in three-dimensionally reconstructed brains by statistical parametric mapping. In non-exercised rats, lesions resulted in persistent motor deficits. Compared to sham-lesioned rats, lesioned rats showed altered functional brain activation during walking, including: 1. hypoactivation of the striatum and motor cortex; 2. hyperactivation of non-lesioned areas in the basal ganglia-thalamocortical circuit; 3. functional recruitment of the red nucleus, superior colliculus and somatosensory cortex; 4. hyperactivation of the ventrolateral thalamus, cerebellar vermis and deep nuclei, suggesting recruitment of the cerebellar-thalamocortical circuit; 5. hyperactivation of limbic areas (amygdala, hippocampus, ventral striatum, septum, raphe, insula). These findings show remarkable similarities to imaging findings reported in PD patients. Exercise progressively improved motor deficits in lesioned rats, while increasing activation in dorsal striatum and rostral secondary motor cortex, attenuating a hyperemia of the zona incerta and eliciting a functional reorganization of regions participating in the cerebellar-thalamocortical circuit. Both lesions and exercise increased activation in mesolimbic areas (amygdala, hippocampus, ventral striatum, laterodorsal tegmental n., ventral pallidum), as well as in related paralimbic regions (septum, raphe, insula). Exercise, but not lesioning, resulted in decreases in rCBF in the medial prefrontal cortex (cingulate, prelimbic, infralimbic). Our results in this PD rat model uniquely highlight the breadth of functional reorganizations in motor and limbic circuits following lesion and long-term, aerobic exercise, and provide a framework for understanding the neural substrates underlying exercise-based neurorehabilitation.
登录
查看更多内容
影响因子：
3.3
作者：
Al-Jarrah, M.;Pothakos, K.;Lau, Y.-S.
通讯作者：
Lau, Y.-S.
影响因子：
3
作者：
Buot, A.;Yelnik, J.
通讯作者：
Yelnik, J.
影响因子：
64.8
作者：
Barnes, TD;Kubota, Y;Graybiel, AM
通讯作者：
Graybiel, AM
影响因子：
3.8
作者：
CADET, JL;LAST, R;JACKSONLEWIS, V
通讯作者：
JACKSONLEWIS, V
影响因子：
3
作者：
Cakit, Burcu Duyur;Saracoglu, Meryern;Inan, Levent
通讯作者：
Inan, Levent