Differences of urinary arsenic metabolites and methylation capacity between individuals with and without skin lesions in Inner Mongolia, Northern China.
Differences of urinary arsenic metabolites and methylation capacity between individuals with and without skin lesions in Inner Mongolia, Northern China.
复制标题
内蒙古、北方地区有无皮损人群尿砷代谢物及甲基化能力差异
DOI：
10.3390/ijerph110707319
复制
发表时间：
2014-07-18
影响因子：
--
通讯作者：
Sun G
中科院分区：
文献类型：
--
作者：
Zhang Q;Li Y;Liu J;Wang D;Zheng Q;Sun G
砷不完全甲基化被认为是砷相关疾病的危险因素。本研究旨在研究有和没有皮肤损伤的受试者之间尿As代谢物和甲基化能力的差异。检测尿液无机砷（iAs）、单甲基拉森酸（MMA）、二甲基拉森酸（DMA）。计算各As种的百分比（iAs%、MMA%和DMA%）、初级甲基化指数（PMI）和次级甲基化指数（SMI）。结果显示，在校正多个混杂因素后，皮肤病变组尿iAs （99.08 vs. 70.63 μg Cr, p = 0.006）和MMA （69.34 vs. 42.85 μg Cr, p = 0.016）水平均高于无皮肤病变组。两组间尿MMA%（15.49比12.11,p = 0.036）、SMI（0.74比0.81,p = 0.025）差异均有统计学意义。本研究的结果表明，有皮肤损伤的受试者可能比没有皮肤损伤的受试者具有更低的As甲基化能力。
Incomplete arsenic (As) methylation has been considered a risk factor of As-related diseases. This study aimed to examine the difference of urinary As metabolites and the methylation capacity between subjects with and without skin lesions. Urinary inorganic arsenic (iAs), monomethylarsonic acid (MMA), and dimethylarsinic acid (DMA) were analyzed. The percentage of each As species (iAs%, MMA%, and DMA%), the primary methylation index (PMI) and secondary methylation index (SMI) were calculated. The results showed that subjects with skin lesions have higher levels of urinary iAs (99.08 vs. 70.63 μg/g Cr, p = 0.006) and MMA (69.34 vs. 42.85 μg/g Cr, p = 0.016) than subjects without skin lesions after adjustment for several confounders. Significant differences of urianry MMA% (15.49 vs. 12.11, p = 0.036) and SMI (0.74 vs. 0.81, p = 0.025) were found between the two groups. The findings of the present study suggest that subjects with skin lesions may have a lower As methylation capacity than subjects without skin lesions.
登录
查看更多内容
DOI：
10.1016/j.mrfmmm.2008.07.003
发表时间：
2009-07-10
影响因子：
2.3
作者：
Engstrom, Karin Schlawicke;Nermell, Barbro;Broberg, Karin
通讯作者：
Broberg, Karin
DOI：
10.3390/ijerph2006030031
发表时间：
2006-09
影响因子：
--
作者：
Guo X;Fujino Y;Ye X;Liu J;Yoshimura T;Japan Inner Mongolia Arsenic Pollution Study Group
通讯作者：
Japan Inner Mongolia Arsenic Pollution Study Group
影响因子：
3.8
作者：
Melak D;Ferreccio C;Kalman D;Parra R;Acevedo J;Pérez L;Cortés S;Smith AH;Yuan Y;Liaw J;Steinmaus C
通讯作者：
Steinmaus C
影响因子：
5
作者：
Argos, Maria;Kalra, Tara;Ahsan, Habibul
通讯作者：
Ahsan, Habibul
影响因子：
10.4
作者：
Concha, G;Nermell, B;Vahter, M
通讯作者：
Vahter, M