Compliance, hysteresis, and collapsibility of human small airways.
Compliance, hysteresis, and collapsibility of human small airways.
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人类小气道的顺应性、滞后性和塌陷性。
DOI：
10.1164/ajrccm.160.4.9709004
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发表时间：
1999
影响因子：
24.7
通讯作者：
J. D. Jongste
中科院分区：
文献类型：
--
作者：
H. Tiddens;W. Hofhuis;J. Bogaard;W. Hop;Huib de Bruin;L. Willems;J. D. Jongste
我们测试了气道壁尺寸是气道机械性能的重要决定因素的假设。31例患有不同程度慢性阻塞性肺疾病（COPD）的吸烟者因单发肺病变而行手术。小气道段（n = 35）在器官浴中安装在套管上，在+15至-15 cm H(2)O之间循环充气和放气。每条气道在基线、服用甲胆碱后和服用异丙肾上腺素后进行。根据每次记录计算特定顺应性（sCdyn）、特定迟滞性（seta）和气道塌陷时的压力（Pcol）。用形态计量学方法测量气道壁尺寸。气流阻塞的肺功能参数与sCdyn、seta、Pcol相关。基线时，服用甲胆碱和异丙肾上腺素后sCdyn分别为0.059、0.052和0。085 cm H(2)O(-)(1)， seta分别为13.5、12.9和7.1%，Pcol分别为-3.4、-3.5和-1.9 cm H(2)O。甲胆碱与异丙肾上腺素治疗后sCdyn、seta、Pcol差异极显著（p < 0.001）。在所有研究的维度中，平滑肌面积，而不是总壁面积，是sCdyn和甲胆碱后seta最重要的决定因素。基线时的比迟滞与残气量占总肺活量的比例（RV/TLC）相关（r = 0.5, p = 0.05），在甲胆碱存在时，与FEV(1)/FVC （r = -0.68, p = 0.02）和RV/TLC （r = 0）相关。5, p = 0.05)。我们得出结论，在这项研究中，平滑肌面积和平滑肌张力，而不是总壁面积，是吸烟者获得的离体气道顺应性、迟滞性和溃散性的决定因素。
We tested the hypothesis that airway wall dimensions are important determinants for the mechanical properties of airways. Lung tissue was obtained from 31 smokers with different degrees of chronic obstructive pulmonary disease (COPD) who were operated on for a solitary lung lesion. Segments of small airways (n = 35) were mounted on cannulas in an organ bath and inflated and deflated cyclically between +15 and -15 cm H(2)O. For each airway this was done at baseline, after methacholine, and after isoprenaline. Specific compliance (sCdyn), specific hysteresis (seta), and pressure at which the airways collapsed (Pcol) were calculated from each recording. Airway wall dimensions were measured morphometrically. Lung function parameters of airflow obstruction were correlated to sCdyn, seta, and Pcol. At baseline, after methacholine, and after isoprenaline sCdyn was 0.059, 0.052, and 0. 085 cm H(2)O(-)(1), seta was 13.5, 12.9, and 7.1%, and Pcol was -3.4, -3.5, and -1.9 cm H(2)O, respectively. Differences between sCdyn, seta, and Pcol after methacholine and after isoprenaline were highly significant (p < 0.001). Of all dimensions studied, smooth muscle area, but not total wall area, was the most important determinant for sCdyn and for seta after methacholine. Specific hysteresis at baseline correlated to residual volume as a fraction of total lung capacity (RV/TLC) (r = 0.5, p = 0.05) and, in the presence of methacholine, to FEV(1)/FVC (r = -0.68, p = 0.02) and RV/TLC (r = 0. 5, p = 0.05). We conclude that, in this study, smooth muscle area and smooth muscle tone, but not total wall area, are determinants for compliance, hysteresis, and collapsibility of isolated airways obtained from smokers.
中年和老年男性的容量历史影响和气道反应性。
DOI：
10.1164/ajrccm.155.3.9117022
发表时间：
1997
期刊：
American journal of respiratory and critical care medicine.
影响因子：
--
作者：
Sparrow,D;O'Connor,GT;Weiss,ST;DeMolles,D;IngramJr,RH
通讯作者：
IngramJr,RH
正常受试者和患有慢性气流阻塞的个体的气道滞后。
DOI：
10.1152/jappl.1985.58.5.1505
发表时间：
1985
期刊：
Journal of applied physiology (Bethesda, Md. : 1985)
影响因子：
--
作者：
Fairshter,RD
通讯作者：
Fairshter,RD
哮喘自发性和急性气流阻塞期间容量历史的影响。
DOI：
10.1164/arrd.1987.135.3.591
发表时间：
1987
期刊：
The American review of respiratory disease
影响因子：
--
作者：
Lim,TK;Pride,NB;IngramJr,RH
通讯作者：
IngramJr,RH