An appraisal of RECQ1 expression in cancer progression.
An appraisal of RECQ1 expression in cancer progression.
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DOI：
10.3389/fgene.2014.00426
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发表时间：
2014
影响因子：
3.7
通讯作者：
Sharma S
中科院分区：
文献类型：
--
作者：
Sharma S
RECQ 1是与癌症易感综合征遗传相关的人类RecQ DNA解旋酶家族中最丰富的成员，并且众所周知其通过DNA修复在基因组稳定性维持中的功能。尽管是第一个在人类中发现的RecQ同源物，但RECQ 1的生物学功能仍然在很大程度上被低估，其与细胞转化的相关性尚不清楚。RECQ 1在许多临床癌症样品中过表达和扩增。通过计算机模拟评估RECQ 1 mRNA在NCI-60癌细胞系中的表达，可预测RECQ 1与癌细胞迁移、侵袭和转移的相关性。与此一致，最新的研究表明RECQ 1参与了基因表达的调节，特别是与癌症进展相关的基因表达。在功能上，沉默RECQ 1表达显着减少细胞增殖、迁移和侵袭。总的来说，这些结果表明，识别RECQ 1在赋予癌细胞增殖和侵袭表型中的作用可能有助于开发阻断原发性肿瘤进展和转移的治疗策略。
RECQ1 is the most abundant member of the human RecQ family of DNA helicases genetically linked with cancer predisposition syndromes and well known for their functions in genome stability maintenance through DNA repair. Despite being the first discovered RecQ homolog in humans, biological functions of RECQ1 have remained largely underappreciated and its relevance to cellular transformation is yet unclear. RECQ1 is overexpressed and amplified in many clinical cancer samples. In silico evaluation of RECQ1 mRNA expression across the NCI-60 cancer cell lines predicts an association of RECQ1 with cancer cell migration, invasion, and metastasis. Consistent with this, latest work implicates RECQ1 in regulation of gene expression, especially of those associated with cancer progression. Functionally, silencing RECQ1 expression significantly reduces cell proliferation, migration, and invasion. Collectively, these results propose that discerning the role of RECQ1 in conferring proliferative and invasive phenotype to cancer cells could be useful in developing therapeutic strategies to block primary tumor progression and metastasis.
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