Structural and functional diversity of the lectin repertoire in teleost fish: relevance to innate and adaptive immunity.
Structural and functional diversity of the lectin repertoire in teleost fish: relevance to innate and adaptive immunity.
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DOI：
10.1016/j.dci.2011.08.011
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发表时间：
2011-12
影响因子：
2.9
通讯作者：
Amzel, L. Mario
中科院分区：
文献类型：
--
作者：
Vasta, Gerardo R.;Nita-Lazar, Mihai;Giomarelli, Barbara;Ahmed, Hafiz;Du, Shaojun;Cammarata, Matteo;Parrinello, Nicolo;Bianchet, Mario A.;Amzel, L. Mario
关键词：
凝集素介导的蛋白质-碳水化合物相互作用被认为是脊椎动物和无脊椎动物天然免疫的关键组成部分，不仅可以识别潜在的病原体，还可以参与下游的效应功能，如凝集、固定和补体介导的调理和杀伤。最近，凝集素被确定为哺乳动物适应性免疫反应的关键调节因子。鱼类几乎具有哺乳动物适应性免疫的所有组成部分，并配备了复杂的凝集素酶系。在这篇综述中，我们讨论了证据表明：(A)硬骨鱼的凝集素酶谱高度多样化，不仅包括哺乳动物中所描述的凝集素家族的代表，还包括首次在鱼类中描述的凝集素家族的成员；(B)不同的凝集素谱系及其分子伴侣的组织特异性表达和定位与它们在先天性免疫和获得性免疫中的不同生物学作用相一致；(C)尽管一些凝集素可能与内源性配体结合，但另一些凝集素可能结合潜在病原体表面的糖；(D)除了病原体识别和调理外，一些凝集素还发挥额外的效应作用，例如激活补体和调节免疫功能；(E)一些识别外源配体的凝集素调节与免疫无关的过程：它们可以作为抗冻蛋白或在受精过程中防止多精症。
Protein–carbohydrate interactions mediated by lectins have been recognized as key components of innate immunity in vertebrates and invertebrates, not only for recognition of potential pathogens, but also for participating in downstream effector functions, such as their agglutination, immobilization, and complement-mediated opsonization and killing. More recently, lectins have been identified as critical regulators of mammalian adaptive immune responses. Fish are endowed with virtually all components of the mammalian adaptive immunity, and are equipped with a complex lectin repertoire. In this review, we discuss evidence suggesting that: (a) lectin repertoires in teleost fish are highly diversified, and include not only representatives of the lectin families described in mammals, but also members of lectin families described for the first time in fish species; (b) the tissue-specific expression and localization of the diverse lectin repertoires and their molecular partners is consistent with their distinct biological roles in innate and adaptive immunity; (c) although some lectins may bind endogenous ligands, others bind sugars on the surface of potential pathogens; (d) in addition to pathogen recognition and opsonization, some lectins display additional effector roles, such as complement activation and regulation of immune functions; (e) some lectins that recognize exogenous ligands mediate processes unrelated to immunity: they may act as anti-freeze proteins or prevent polyspermia during fertilization.
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影响因子：
3.7
作者：
Graham LA;Lougheed SC;Ewart KV;Davies PL
通讯作者：
Davies PL
影响因子：
56.9
作者：
Harvell, CD;Kim, K;Vasta, GR
通讯作者：
Vasta, GR
影响因子：
2.8
作者：
Dodds, AW
通讯作者：
Dodds, AW
DOI：
10.1038/nsb817
发表时间：
2002-08-01
期刊：
NATURE STRUCTURAL BIOLOGY
影响因子：
--
作者：
Bianchet, MA;Odom, EW;Amzel, LM
通讯作者：
Amzel, LM
影响因子：
2.9
作者：
Fuller, JR;Pitzer, JE;McConnell, TJ
通讯作者：
McConnell, TJ