Global Brain Functional Network Connectivity in Infants With Prenatal Opioid Exposure.
Global Brain Functional Network Connectivity in Infants With Prenatal Opioid Exposure.
复制标题
产前阿片类药物暴露的婴儿的全球脑功能网络连通性。
DOI：
10.3389/fped.2022.847037
复制
发表时间：
2022
影响因子：
2.6
通讯作者：
Sadhasivam S
中科院分区：
文献类型：
--
作者：
Radhakrishnan R;Vishnubhotla RV;Zhao Y;Yan J;He B;Steinhardt N;Haas DM;Sokol GM;Sadhasivam S
产前阿片类药物和物质暴露的婴儿在儿童后期神经行为结果不良的风险更高。婴儿期的早期脑成像有可能识别早期脑发育变化，这可能有助于预测这些儿童的行为结果。在这项研究中，使用婴儿早期的静息状态功能性MRI，我们的目标是确定与健康对照婴儿相比，产前阿片类药物和物质暴露的婴儿在全球脑网络连接方面的差异。在这项前瞻性研究中，我们招募了23名产前阿片类药物暴露的婴儿和29名健康的阿片类药物初治婴儿。所有受试者在月经后3个月前接受脑静息态功能MRI检查。进行协变量辅助主（CAP）回归，以确定在调整性别和胎龄后功能连接与阿片类药物暴露相关的脑网络。还评估了这些重要网络与母体合并症的相关性。此外，在这些CAP网络中评估了图形网络度量。有四个CAP网络组件之间的阿片类药物暴露和健康对照婴儿显着不同。这四个网络中有两个与母亲的心理因素有关。与健康对照组相比，阿片类药物暴露婴儿的网络内图指标，即平均流量系数，聚类系数和传递性也有显着差异。与非阿片类药物暴露的婴儿相比，产前阿片类药物暴露与全球脑功能网络的改变相关，图网络建模中的网络内改变。这些网络的改变也与母亲的合并症，特别是心理健康。大规模纵向研究可以帮助了解产前接触阿片类药物的婴儿的这些早期脑功能网络改变的临床意义。
Infants with prenatal opioid and substance exposure are at higher risk of poor neurobehavioral outcomes in later childhood. Early brain imaging in infancy has the potential to identify early brain developmental alterations that may help predict behavioral outcomes in these children. In this study, using resting-state functional MRI in early infancy, we aim to identify differences in global brain network connectivity in infants with prenatal opioid and substance exposure compared to healthy control infants. In this prospective study, we recruited 23 infants with prenatal opioid exposure and 29 healthy opioid naïve infants. All subjects underwent brain resting-state functional MRI before 3 months postmenstrual age. Covariate Assisted Principal (CAP) regression was performed to identify brain networks within which functional connectivity was associated with opioid exposure after adjusting for sex and gestational age. Associations of these significant networks with maternal comorbidities were also evaluated. Additionally, graph network metrics were assessed in these CAP networks. There were four CAP network components that were significantly different between the opioid exposed and healthy control infants. Two of these four networks were associated with maternal psychological factors. Intra-network graph metrics, namely average flow coefficient, clustering coefficient and transitivity were also significantly different in opioid exposed infants compared to healthy controls. Prenatal opioid exposure is associated with alterations in global brain functional networks compared to non-opioid exposed infants, with intra-network alterations in graph network modeling. These network alterations were also associated with maternal comorbidity, especially mental health. Large-scale longitudinal studies can help in understanding the clinical implications of these early brain functional network alterations in infants with prenatal opioid exposure.
登录
查看更多内容
影响因子：
8
作者：
Fill MA;Miller AM;Wilkinson RH;Warren MD;Dunn JR;Schaffner W;Jones TF
通讯作者：
Jones TF
影响因子：
5.7
作者：
Batalle, Dafnis;Eixarch, Elisenda;Gratacos, Eduard
通讯作者：
Gratacos, Eduard
影响因子：
2.5
作者：
Konijnenberg, Carolien;Sarfi, Monica;Melinder, Annika
通讯作者：
Melinder, Annika
DOI：
10.1016/s0889-8545(05)70362-4
发表时间：
1998-03-01
影响因子：
3.2
作者：
Kaltenbach, K;Berghella, V;Finnegan, L
通讯作者：
Finnegan, L
影响因子：
26.1
作者：
Dean DC 3rd;Planalp EM;Wooten W;Kecskemeti SR;Adluru N;Schmidt CK;Frye C;Birn RM;Burghy CA;Schmidt NL;Styner MA;Short SJ;Kalin NH;Goldsmith HH;Alexander AL;Davidson RJ
通讯作者：
Davidson RJ