Association of Prenatal Maternal Depression and Anxiety Symptoms With Infant White Matter Microstructure.
Association of Prenatal Maternal Depression and Anxiety Symptoms With Infant White Matter Microstructure.
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DOI：
10.1001/jamapediatrics.2018.2132
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发表时间：
2018-10-01
期刊：
影响因子：
26.1
通讯作者：
Davidson RJ
中科院分区：
文献类型：
--
作者：
Dean DC 3rd;Planalp EM;Wooten W;Kecskemeti SR;Adluru N;Schmidt CK;Frye C;Birn RM;Burghy CA;Schmidt NL;Styner MA;Short SJ;Kalin NH;Goldsmith HH;Alexander AL;Davidson RJ
母亲的抑郁和焦虑会对儿童的发育产生有害的终身影响。然而，早期大脑发育与母体症状之间的关联的许多方面仍然不清楚。了解潜在神经生物学改变的时间对于未来治疗和干预的开发和评估具有内在价值。研究产前母亲抑郁和焦虑症状暴露与1月龄时后代白色微结构之间的关系。这项对101对母婴进行的队列研究使用了在妊娠晚期测量的母亲抑郁和焦虑症状的复合指标，以及在2014年10月1日至2016年11月30日期间使用扩散张量成像和神经突方向弥散和密度成像对母亲1个月的后代进行的白色物质微结构测量。磁共振成像是在一个学术研究机构进行的，在自然，非镇静睡眠。脑映射算法和统计模型被用来评估母亲抑郁和焦虑与1个月婴儿白色物质微结构之间的关联，通过扩散张量成像和神经突方向分散和密度成像结果进行测量。在101对母婴中（母亲的平均[SD]年龄，33.22 [3.99]岁;磁共振成像时婴儿的平均年龄，33.07天[范围，18-50天]; 92名白色母亲[91.1%]; 53例男婴[52.5%]），1个月白色物质显微结构较低（神经突密度降低和平均、径向和轴向扩散率增加）与右额叶白色质微结构中较高的产前母亲抑郁和焦虑症状相关。还观察到显著的性别×症状与白色物质微观结构测量的相互作用，表明白色物质发育可能对产前男性和女性的母亲抑郁和焦虑症状具有不同的敏感性。这些数据突出了产前时期对早期大脑发育的重要性，并表明潜在的白色物质微观结构与产前母亲抑郁和焦虑症状的连续性有关。
Maternal depression and anxiety can have deleterious and lifelong consequences on child development. However, many aspects of the association of early brain development with maternal symptoms remain unclear. Understanding the timing of potential neurobiological alterations holds inherent value for the development and evaluation of future therapies and interventions. To examine the association between exposure to prenatal maternal depression and anxiety symptoms and offspring white matter microstructure at 1 month of age. This cohort study of 101 mother-infant dyads used a composite of depression and anxiety symptoms measured in mothers during the third trimester of pregnancy and measures of white matter microstructure characterized in the mothers’ 1-month offspring using diffusion tensor imaging and neurite orientation dispersion and density imaging performed from October 1, 2014, to November 30, 2016. Magnetic resonance imaging was performed at an academic research facility during natural, nonsedated sleep. Brain mapping algorithms and statistical models were used to evaluate the association between maternal depression and anxiety and 1-month infant white matter microstructure as measured by diffusion tensor imaging and neurite orientation dispersion and density imaging findings. In the 101 mother-infant dyads (mean [SD] age of mothers, 33.22 [3.99] years; mean age of infants at magnetic resonance imaging, 33.07 days [range, 18–50 days]; 92 white mothers [91.1%]; 53 male infants [52.5%]), lower 1-month white matter microstructure (decreased neurite density and increased mean, radial, and axial diffusivity) was associated in right frontal white matter microstructure with higher prenatal maternal symptoms of depression and anxiety. Significant sex × symptom interactions with measures of white matter microstructure were also observed, suggesting that white matter development may be differentially sensitive to maternal depression and anxiety symptoms in males and females during the prenatal period. These data highlight the importance of the prenatal period to early brain development and suggest that the underlying white matter microstructure is associated with the continuum of prenatal maternal depression and anxiety symptoms.
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影响因子：
3.1
作者：
Dean DC 3rd;Planalp EM;Wooten W;Schmidt CK;Kecskemeti SR;Frye C;Schmidt NL;Goldsmith HH;Alexander AL;Davidson RJ
通讯作者：
Davidson RJ
影响因子：
2.3
作者：
Dean, Douglas C., III;Dirks, Holly;O'Muircheartaigh, Jonathan;Walker, Lindsay;Jerskey, Beth A.;Lehman, Katie;Han, Michelle;Waskiewicz, Nicole;Deoni, Sean C. L.
通讯作者：
Deoni, Sean C. L.
影响因子：
3.3
作者：
Chang, LC;Jones, DK;Pierpaoli, C
通讯作者：
Pierpaoli, C
影响因子：
3.1
作者：
Dean DC 3rd;O'Muircheartaigh J;Dirks H;Waskiewicz N;Walker L;Doernberg E;Piryatinsky I;Deoni SC
通讯作者：
Deoni SC
影响因子：
5.2
作者：
Avan, Bilal;Richter, Linda M.;Stein, Alan
通讯作者：
Stein, Alan