Impact of Helminth Infection on Metabolic and Immune Homeostasis in Non-diabetic Obesity.
Impact of Helminth Infection on Metabolic and Immune Homeostasis in Non-diabetic Obesity.
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DOI：
10.3389/fimmu.2020.02195
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发表时间：
2020
影响因子：
7.3
通讯作者：
Babu S
中科院分区：
文献类型：
--
作者：
Rajamanickam A;Munisankar S;Thiruvengadam K;Menon PA;Dolla C;Nutman TB;Babu S
一些流行病学和免疫学研究表明，肥胖/代谢综合征和蠕虫感染之间存在相互关联。大量研究表明，肥胖伴随着慢性低度炎症，其特征在于脂肪组织的细胞组成和功能的重要变化。然而，寄生虫感染对肥胖患者体内平衡环境的影响尚不清楚。为了确定粪类圆线虫（Ss）感染和肥胖之间的关系，我们检查了一系列与肥胖相关的参数，包括驱虫治疗前和治疗后6个月。为此，我们测量了血清胰腺激素，肠促胰岛素，脂肪因子和1型，2型，17型，和其他促炎细胞因子在那些非糖尿病肥胖（INF）或无Ss感染（UN）。在INF个体中，我们在驱虫治疗后6个月评估了这些参数的水平。与联合国个体相比，INF个体的胰岛素、胰高血糖素、C肽和GLP-1水平显著降低，GIP水平显著升高。与UN个体相比，INF个体还显示出显著较低水平的1型、17型和其他促炎细胞因子，以及显著增加水平的2型和调节细胞因子。大多数这些变化显着逆转驱虫治疗后。在肥胖个体中，Ss感染与胰腺激素、肠促胰岛素、脂肪因子和细胞因子的显著改变以及驱虫治疗后的部分逆转有关。我们的数据提供了一个可能的生物学机制，Ss感染对肥胖的保护作用。
Several epidemiological and immunological studies indicate a reciprocal association between obesity/metabolic syndrome and helminth infections. Numerous studies demonstrated that obesity is concomitant with chronic low-grade inflammation, which is marked by vital changes in cellular composition and function of adipose tissue. However, the effect of helminth infection on the homeostatic milieu in obesity is not well-understood. To determine the relationship between Strongyloides stercoralis (Ss) infection and obesity, we examined an array of parameters linked with obesity both before and at 6 months following anthelmintic treatment. To this end, we measured serum levels of pancreatic hormones, incretins, adipokines and Type-1, Type-2, Type-17, and other proinflammatory cytokines in those with non-diabetic obesity with (INF) or without Ss infection (UN). In INF individuals, we evaluated the levels of these parameters at 6 months following anthelmintic treatment. INF individuals revealed significantly lower levels of insulin, glucagon, C-peptide, and GLP-1 and significantly elevated levels of GIP compared to UN individuals. INF individuals also showed significantly lower levels of Type-1, Type-17 and other pro-inflammatory cytokines and significantly increased levels of Type-2 and regulatory cytokines in comparison to UN individuals. Most of these changes were significantly reversed following anthelmintic treatment. Ss infection is associated with a significant alteration of pancreatic hormones, incretins, adipokines, and cytokines in obese individuals and its partial reversal following anthelmintic treatment. Our data offer a possible biological mechanism for the protective effect of Ss infection on obesity.
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影响因子：
3.8
作者：
Hotez PJ;Alvarado M;Basáñez MG;Bolliger I;Bourne R;Boussinesq M;Brooker SJ;Brown AS;Buckle G;Budke CM;Carabin H;Coffeng LE;Fèvre EM;Fürst T;Halasa YA;Jasrasaria R;Johns NE;Keiser J;King CH;Lozano R;Murdoch ME;O'Hanlon S;Pion SD;Pullan RL;Ramaiah KD;Roberts T;Shepard DS;Smith JL;Stolk WA;Undurraga EA;Utzinger J;Wang M;Murray CJ;Naghavi M
通讯作者：
Naghavi M
影响因子：
3.8
作者：
Aravindhan V;Mohan V;Surendar J;Muralidhara Rao M;Pavankumar N;Deepa M;Rajagopalan R;Kumaraswami V;Nutman TB;Babu S
通讯作者：
Babu S
影响因子：
2.2
作者：
Shen, S. -W.;Lu, Y.;Tong, D. -X.
通讯作者：
Tong, D. -X.
影响因子：
4.8
作者：
Hussaarts, Leonie;Garcia-Tardon, Noemi;Guigas, Bruno
通讯作者：
Guigas, Bruno
影响因子：
5.1
作者：
Hays, Russell;Esterman, Adrian;McDermott, Robyn
通讯作者：
McDermott, Robyn