Early-stage macular telangiectasia type 2 vascular abnormalities are associated with interdigitation zone disruption.
Early-stage macular telangiectasia type 2 vascular abnormalities are associated with interdigitation zone disruption.
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DOI：
10.1371/journal.pone.0259811
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发表时间：
2021
期刊：
影响因子：
3.7
通讯作者：
Fawzi AA
中科院分区：
文献类型：
--
作者：
Ong JX;Zandi R;Fawzi AA
目的 研究 2 型黄斑毛细血管扩张症 (MacTel) 眼中不同感光层破坏与深部毛细血管丛 (DCP) 毛细血管扩张之间的关系。包括 35 只眼睛（21 名患者），使用 MacTel 通过光学相干断层扫描血管造影 (OCTA) 进行成像。从 OCTA 板中追踪 DCP 毛细血管扩张的边界区域，并使用相应的谱域 OCT (SD-OCT) 板来可视化感光层交错区 (IZ) 和椭圆体区 (EZ)。通过检查正面 SD-OCT 板的低反射区域并确认其在横截面视图上的状态，对 IZ 衰减、IZ 损失和 EZ 损失进行分级。根据基于 OCT 的 MacTel 分期评估光感受器破坏的总面积以及与 DCP 毛细血管扩张的重叠。通过后续影像学评估了一部分患者的纵向变化。随着 MacTel 严重程度的增加，DCP 毛细血管扩张与 IZ 衰减的重叠显着减少，而与 IZ 和 EZ 损失的重叠显着增加。与 IZ 损失的重叠在中等 MacTel 中达到顶峰（第 3-5 阶段）。纵向成像显示 6 个月时新的 EZ 丢失很大程度上是通过基线 IZ 丢失来预测的。 MacTel 严重程度恶化的特点是 DCP 毛细血管扩张和光感受器破坏严重程度增加的区域之间有更大的重叠，在先前存在的 IZ 破坏区域内，EZ 损失随着时间的推移而扩大。我们认为 IZ 破坏可能表明早期光感受器功能障碍，最终发展为 EZ 损失，IZ 损失是比 IZ 衰减更可靠的指标。需要进行更多研究来进一步探索 MacTel 的长期光感受器变化并评估它们与视觉功能的关系。
To investigate the relationship between disruption in different photoreceptor layers and deep capillary plexus (DCP) telangiectasias in eyes with macular telangiectasia type 2 (MacTel). 35 eyes (21 patients) with MacTel imaged with optical coherence tomography angiography (OCTA) were included. Circumscribed areas of DCP telangiectasia were traced from OCTA slabs and the corresponding spectral-domain OCT (SD-OCT) slabs were used to visualize the photoreceptor layer interdigitation zone (IZ) and ellipsoid zone (EZ). IZ attenuation, IZ loss, and EZ loss were graded by reviewing en face SD-OCT slabs for hypo-reflective areas and confirming their status on cross-sectional views. Total area of photoreceptor disruption and overlap with DCP telangiectasia were evaluated with respect to OCT-based MacTel stage. Longitudinal changes were evaluated in a subset of patients with follow-up imaging. Overlap of DCP telangiectasia with IZ attenuation significantly decreased with MacTel severity, while overlap with IZ and EZ loss significantly increased. Overlap with IZ loss peaked in moderate MacTel (Stages 3–5). Longitudinal imaging showed that new EZ loss at 6 months was largely predicted by baseline IZ loss. Worsening MacTel severity is characterized by greater overlap between DCP telangiectasia and zones of increasing severity of photoreceptor disruption, with EZ loss enlarging over time within areas of preexisting IZ disruption. We suggest that IZ disruption may indicate early photoreceptor dysfunction that eventually progresses to EZ loss, with IZ loss being a more reliable metric than IZ attenuation. Additional studies will be necessary to further explore long-term photoreceptor changes and evaluate their relationship with visual function in MacTel.
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影响因子：
3.8
作者：
Jia Y;Tan O;Tokayer J;Potsaid B;Wang Y;Liu JJ;Kraus MF;Subhash H;Fujimoto JG;Hornegger J;Huang D
通讯作者：
Huang D
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通讯作者：
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作者：
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通讯作者：
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影响因子：
34.7
作者：
Goldman, Daniel
通讯作者：
Goldman, Daniel