CXCR7-mediated progression of osteosarcoma in the lungs.
CXCR7-mediated progression of osteosarcoma in the lungs.
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DOI：
10.1038/bjc.2013.482
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发表时间：
2013-09-17
影响因子：
8.8
通讯作者：
Schmid-Antomarchi, H.
中科院分区：
文献类型：
--
作者：
Goguet-Surmenian, E.;Richard-Fiardo, P.;Guillemot, E.;Benchetrit, M.;Gomez-Brouchet, A.;Buzzo, P.;Karimdjee-Soilihi, B.;Alemanno, P.;Michiels, J-F;Schmid-Alliana, A.;Schmid-Antomarchi, H.
骨肉瘤（OS）是儿童和青少年中最常见的原发性恶性骨肿瘤，具有高度的肺转移倾向。趋化因子和趋化因子受体在包括OS在内的许多恶性肿瘤中具有重要作用。本研究的目的是探讨CXCR7受体在OS组织中的表达及其在肺疾病进展中的作用。免疫组织化学方法研究了肿瘤原发肿瘤和转移组织中CXCR7的表达。使用动物模型和合成特异性CXCR7配体也评估了其对肺部肿瘤扩张的贡献。CXCR7在人原发性骨肿瘤和肺转移瘤中表达。其表达主要位于肿瘤相关血管。与未处理的小鼠相比，接受OS细胞攻击并系统地接受合成CXCR7配体治疗的小鼠肺结节显著减少。本研究表明，CXCR7在肺OS进展中起关键作用，其中表达CXCR7配体，特别是CXCL12。此外，我们强调合成的CXCR7配体可以作为一种强大的治疗工具来阻止肺OS的进展。
Osteosarcoma (OS) is the most frequent primary malignant bone tumour in children and adolescents with a high propensity for lung metastasis. Chemokines and chemokine receptors have been described to have an important role in many malignancies including OS. The aim of this study was to investigate the expression of CXCR7 receptor in OS tissues and its role in the progression of the disease in the lungs. Immunohistochemistry was used to study CXCR7 expression in primary tumours and metastatic tissues from patients with OS. Its contribution to tumour expansion in the lungs has been also assessed using animal models and synthetic-specific CXCR7 ligands. CXCR7 was expressed on human primary bone tumours and on lung metastases. Its expression was predominantly located on tumour-associated blood vessels. Mice challenged with OS cells and systematically treated with synthetic CXCR7 ligands presented a significant reduction of lung nodules compared with untreated mice. This study shows that CXCR7 has a critical role in OS progression in the lungs, where are expressed CXCR7 ligands, especially CXCL12. Moreover, we highlight that synthetic CXCR7 ligands could represent a powerful therapeutic tool to impede lung OS progression.
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影响因子：
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作者：
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通讯作者：
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作者：
Guillemot, E.;Karimdjee-Soilihi, B.;Pradelli, E.;Benchetrit, M.;Goguet-Surmenian, E.;Millet, M-A;Larbret, F.;Michiels, J-F;Birnbaum, D.;Alemanno, P.;Schmid-Antomarchi, H.;Schmid-Alliana, A.
通讯作者：
Schmid-Alliana, A.
影响因子：
56.9
作者：
LOHSE, MJ;BENOVIC, JL;LEFKOWITZ, RJ
通讯作者：
LEFKOWITZ, RJ