CXCR7 receptors facilitate the progression of colon carcinoma within lung not within liver.
CXCR7 receptors facilitate the progression of colon carcinoma within lung not within liver.
复制标题
DOI：
10.1038/bjc.2012.503
复制
发表时间：
2012-12-04
影响因子：
8.8
通讯作者：
Schmid-Alliana, A.
中科院分区：
文献类型：
--
作者：
Guillemot, E.;Karimdjee-Soilihi, B.;Pradelli, E.;Benchetrit, M.;Goguet-Surmenian, E.;Millet, M-A;Larbret, F.;Michiels, J-F;Birnbaum, D.;Alemanno, P.;Schmid-Antomarchi, H.;Schmid-Alliana, A.
肝和肺转移是结直肠癌（CRC）相关死亡率的主要原因。趋化因子受体对在确定肿瘤的转移进展中具有关键作用。我们的假设是CXCR 7/CXCR 7配体轴的破坏可能导致CRC转移的减少。对来自CRC患者的原发性肿瘤和转移性组织检测CXCR 7及其配体的表达。然后在小鼠中使用小的药理学CXCR 7拮抗剂和人和鼠来源的CRC细胞系研究CXCR 7/CXCR 7配体与CRC转移的相关性，所述细胞系注射到小鼠中使得能够发展肺和肝转移。在注射CRC细胞后，每天用CXCR 7拮抗剂治疗的小鼠表现出肺转移的显著减少。然而，CXCR 7拮抗剂未能降低肝转移的程度。CXCR 7及其配体在肺转移瘤和肝转移瘤中的表达存在细微差异。我们的研究表明，CXCR 7的配体激活肿瘤血管可能会促进肺内而不是肝内CRC的进展。此外，我们提供的证据表明，靶向CXCR 7轴可能有利于限制结肠癌在肺内的转移。
Liver and lung metastases are the predominant cause of colorectal cancer (CRC)-related mortality. Chemokine-receptor pairs have a critical role in determining the metastatic progression of tumours. Our hypothesis was that disruption of CXCR7/CXCR7 ligands axis could lead to a decrease in CRC metastases. Primary tumours and metastatic tissues from patients with CRC were tested for the expression of CXCR7 and its ligands. Relevance of CXCR7/CXCR7 ligands for CRC metastasis was then investigated in mice using small pharmacological CXCR7 antagonists and CRC cell lines of human and murine origins, which – injected into mice – enable the development of lung and liver metastases. Following injection of CRC cells, mice treated daily with CXCR7 antagonists exhibited a significant reduction in lung metastases. However, CXCR7 antagonists failed to reduce the extent of liver metastasis. Moreover, there were subtle differences in the expression of CXCR7 and its ligands between lung and liver metastases. Our study suggests that the activation of CXCR7 on tumour blood vessels by its ligands may facilitate the progression of CRC within lung but not within liver. Moreover, we provide evidence that targeting the CXCR7 axis may be beneficial to limit metastasis from colon cancer within the lungs.
登录
查看更多内容
影响因子：
8.8
作者：
通讯作者：
--
影响因子：
6.2
作者：
Iwakiri, Shotaro;Mino, Nobuya;Miyahara, Ryo
通讯作者：
Miyahara, Ryo
影响因子：
9.2
作者：
Sun, Xueqing;Cheng, Guangcun;Hao, Mingang;Zheng, Jianghua;Zhou, Xiaoming;Zhang, Jian;Taichman, Russell S.;Pienta, Kenneth J.;Wang, Jianhua
通讯作者：
Wang, Jianhua
影响因子：
3.7
作者：
Keeley EC;Mehrad B;Strieter RM
通讯作者：
Strieter RM
影响因子：
7.5
作者：
Mirshahi, F;Pourtau, J;Soria, C
通讯作者：
Soria, C