Corin: A Key Mediator in Sodium Homeostasis, Vascular Remodeling, and Heart Failure.
Corin: A Key Mediator in Sodium Homeostasis, Vascular Remodeling, and Heart Failure.
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Corin：钠稳态、血管重塑和心力衰竭的关键介质
DOI：
10.3390/biology11050717
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发表时间：
2022-05-07
期刊：
影响因子：
4.2
通讯作者：
Wu, Qingyu
中科院分区：
文献类型：
--
作者：
Zhang, Xianrui;Gu, Xiabing;Zhang, Yikai;Dong, Ningzheng;Wu, Qingyu
关键词：
心房钠尿肽（ANP）是一种重要的激素，调节多种生理和病理过程，包括电解质和体液平衡、血容量和血压、心通道活动和功能、炎症反应、脂质代谢和血管重塑。Corin是激活ANP的跨膜丝氨酸蛋白酶。CORIN基因的变异与心血管疾病相关，包括高血压、心脏肥大、心房纤颤、心力衰竭和先兆子痫。目前的数据表明corin介导的心钠素的生产和信号在维持心血管稳态的关键作用。在这篇综述中，我们讨论了最新的研究结果有关的分子和细胞机制的作用，corin钠稳态，子宫螺旋动脉重塑，心力衰竭。心房利钠肽（ANP）是心脏内分泌功能的重要组成部分，可促进尿钠排泄、利尿和血管舒张，从而保护正常血压和心脏功能。Corin是一种II型跨膜丝氨酸蛋白酶，在心脏中高度表达，在心脏中将ANP前体转化为成熟ANP。Corin缺乏会阻止ANP激活并导致高血压和心脏病。除心脏外，corin还在其他组织中表达，包括肾脏、皮肤和子宫，corin介导的ANP产生和信号传导在这些组织中局部作用以促进钠排泄和血管重塑。这些结果表明corin和ANP通过内分泌和自分泌机制在许多组织中起作用。在心力衰竭患者中，利钠肽加工受损是导致钠和体液潴留的常见病理机制。在这篇综述中，我们讨论了最新的研究结果corin在非心脏组织中的作用，包括肾脏和皮肤，在调节钠稳态和体液排泄。此外，我们还描述了corin和ANP在支持子宫螺旋动脉重塑中有序细胞事件中的分子机制。最后，我们评估了以corin为基础的方法作为心力衰竭治疗方法来增强利钠肽的产生和活性的潜力。
Atrial natriuretic peptide (ANP) is an important hormone that regulates many physiological and pathological processes, including electrolyte and body fluid balance, blood volume and pressure, cardiac channel activity and function, inflammatory response, lipid metabolism, and vascular remodeling. Corin is a transmembrane serine protease that activates ANP. Variants in the CORIN gene are associated with cardiovascular disease, including hypertension, cardiac hypertrophy, atrial fibrillation, heart failure, and preeclampsia. The current data indicate a key role of corin-mediated ANP production and signaling in the maintenance of cardiovascular homeostasis. In this review, we discuss the latest findings regarding the molecular and cellular mechanisms underlying the role of corin in sodium homeostasis, uterine spiral artery remodeling, and heart failure. Atrial natriuretic peptide (ANP) is a crucial element of the cardiac endocrine function that promotes natriuresis, diuresis, and vasodilation, thereby protecting normal blood pressure and cardiac function. Corin is a type II transmembrane serine protease that is highly expressed in the heart, where it converts the ANP precursor to mature ANP. Corin deficiency prevents ANP activation and causes hypertension and heart disease. In addition to the heart, corin is expressed in other tissues, including those of the kidney, skin, and uterus, where corin-mediated ANP production and signaling act locally to promote sodium excretion and vascular remodeling. These results indicate that corin and ANP function in many tissues via endocrine and autocrine mechanisms. In heart failure patients, impaired natriuretic peptide processing is a common pathological mechanism that contributes to sodium and body fluid retention. In this review, we discuss most recent findings regarding the role of corin in non-cardiac tissues, including the kidney and skin, in regulating sodium homeostasis and body fluid excretion. Moreover, we describe the molecular mechanisms underlying corin and ANP function in supporting orderly cellular events in uterine spiral artery remodeling. Finally, we assess the potential of corin-based approaches to enhance natriuretic peptide production and activity as a treatment of heart failure.
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影响因子：
3.2
作者：
Best, Andrew;Kamilar, Jason M.
通讯作者：
Kamilar, Jason M.
DOI：
10.1038/nrneph.2014.102
发表时间：
2014-08
期刊：
Nature reviews. Nephrology
影响因子：
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作者：
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DOI：
10.1042/cs20160398
发表时间：
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期刊：
Clinical science (London, England : 1979)
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DOI：
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2005-01-18
影响因子：
11.1
作者：
Chan, JCY;Knudson, O;Wu, QY
通讯作者：
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DOI：
10.1111/jch.14400
发表时间：
2022-03
期刊：
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