Brain gray matter differences among forensic psychiatric patients with psychosis and incarcerated individuals without psychosis: A source-based morphometry study.
Brain gray matter differences among forensic psychiatric patients with psychosis and incarcerated individuals without psychosis: A source-based morphometry study.
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大脑灰质差异患有精神病的法医精神病患者和没有精神病的被监禁的个体：基于源的形态计量学研究。
DOI：
10.1016/j.nicl.2021.102673
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发表时间：
2021
期刊：
影响因子：
--
通讯作者：
Kiehl KA
中科院分区：
文献类型：
--
作者：
Kolla NJ;Harenski CL;Harenski KA;Dupuis M;Crawford JJ;Kiehl KA
We employed source-based morphometry to examine grey matter differences in forensic psychiatric patients with psychosis versus incarcerated controls without psychosis. Compared to the psychotic group, the non-psychotic group demonstrated greater loading weights in the superior, transverse, and middle temporal gyrus and the anterior cingulate. Compared to the non-psychotic group, the psychotic group exhibited greater loading weights in the frontal pole, precuneus, basal ganglia, thalamus, parahippocampal gyrus, and visual cortex. Neuroimaging investigations of offenders with psychosis ought to control for the level of psychopathic traits present. While psychosis is a risk factor for violence, the majority of individuals who perpetrate aggression do not present psychotic symptoms. Pathological aggressive behavior is associated with brain gray matter differences, which, in turn, has shown a relationship with increased psychopathic traits. However, no study, to our knowledge, has ever investigated gray matter differences in forensic psychiatric patients with psychosis compared with incarcerated individuals without psychosis matched on levels of psychopathic traits. Here, we employed source-based morphometry (SBM) to investigate gray matter differences in these two populations. We scanned 137 participants comprising two offender subgroups: 69, non-psychotic incarcerated offenders and 68, psychotic, forensic psychiatric patients. Groups showed no difference in age, race, ethnicity, handedness, and Hare Psychopathy Checklist-Revised scores. Source-based morphometry was utilized to identify spatially distinct sets of brain regions where gray matter volumes covaried between groups. SBM is a data-driven, multivariate technique that uses independent components analysis to categorize groups of voxels that display similar variance patterns (e.g., components) that are compared across groups. SBM identified four components that differed between groups. These findings indicated greater loading weights in the superior, transverse, and middle temporal gyrus and anterior cingulate in the non-psychotic versus psychotic group; greater loading weights in the basal ganglia in the psychotic versus non-psychotic group; greater loading weights in the frontal pole, precuneus, and visual cortex among psychotic versus non-psychotic offenders; and greater loading weights in the thalamus and parahippocampal gyrus in psychotic versus non-psychotic groups. Two different offender groups that perpetrate violence and show comparable levels of psychopathic traits evidenced different gray matter volumes. We suggest that future studies of violent offenders with psychosis take psychopathic traits into account to refine neural phenotypes.
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影响因子：
4.6
作者：
Ermer, Elsa;Cope, Lora M.;Nyalakanti, Prashanth K.;Calhoun, Vince D.;Kiehl, Kent A.
通讯作者：
Kiehl, Kent A.
精神分裂症攻击行为的神经影像学相关性：更新。
影响因子：
6.9
作者：
Hoptman MJ;Antonius D
通讯作者：
Antonius D
影响因子：
4.7
作者：
Fjellvang M;Grøning L;Haukvik UK
通讯作者：
Haukvik UK
影响因子：
--
作者：
Gur, RE;Cowell, PE;Gur, RC
通讯作者：
Gur, RC
DOI：
10.1016/j.jaac.2012.10.013
发表时间：
2013-01
影响因子：
13.3
作者：
Ermer E;Cope LM;Nyalakanti PK;Calhoun VD;Kiehl KA
通讯作者：
Kiehl KA