Fusiform Gyrus Phospho-Tau is Associated with Failure of Proper Name Retrieval in Aging.
Fusiform Gyrus Phospho-Tau is Associated with Failure of Proper Name Retrieval in Aging.
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DOI:
10.1002/ana.26237
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发表时间:
2021-12
影响因子:
11.2
通讯作者:
Jagust WJ
中科院分区:
文献类型:
--
作者:
Tennant VR;Harrison TM;Adams JN;La Joie R;Winer JR;Jagust WJ
Difficulty retrieving proper names is common in older adults, coinciding with the accumulation of aggregated proteins in mid-life. We investigated the ability of healthy older adults to retrieve the names of famous faces in relation to positron emission tomography measurements of amyloid-β plaques and tau neurofibrillary tangles. More tau in the left fusiform and parahippocampal gyrus was related to reduced proper name retrieval performance and this effect was potentiated by amyloid-β. These findings provide an explanation for a common complaint of older adults and link proper name retrieval to neural systems involved in face perception, memory, and naming.
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