Fusiform Gyrus Phospho-Tau is Associated with Failure of Proper Name Retrieval in Aging.

Fusiform Gyrus Phospho-Tau is Associated with Failure of Proper Name Retrieval in Aging.
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DOI:
10.1002/ana.26237
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发表时间:
2021-12
影响因子:
11.2
通讯作者:
Jagust WJ
Jagust WJ
中科院分区:
医学1区
文献类型:
--
作者:
Tennant VR;Harrison TM;Adams JN;La Joie R;Winer JR;Jagust WJ

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在老年人中,难以检索专有名称是很常见的,这与中年时聚集蛋白质的积累相吻合。我们调查了健康老年人检索与正电子发射断层扫描测量的淀粉样蛋白-β斑块和tau神经元缠结相关的著名面孔的名字的能力。左侧梭状回和海马旁回中更多的tau蛋白与专有名称提取能力降低有关,β淀粉样蛋白增强了这种作用。这些发现为老年人的常见抱怨提供了解释,并将专有名称检索与涉及面部感知,记忆和命名的神经系统联系起来。
Difficulty retrieving proper names is common in older adults, coinciding with the accumulation of aggregated proteins in mid-life. We investigated the ability of healthy older adults to retrieve the names of famous faces in relation to positron emission tomography measurements of amyloid-β plaques and tau neurofibrillary tangles. More tau in the left fusiform and parahippocampal gyrus was related to reduced proper name retrieval performance and this effect was potentiated by amyloid-β. These findings provide an explanation for a common complaint of older adults and link proper name retrieval to neural systems involved in face perception, memory, and naming.
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