Face-name associative memory performance is related to amyloid burden in normal elderly.
Face-name associative memory performance is related to amyloid burden in normal elderly.
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DOI：
10.1016/j.neuropsychologia.2011.06.006
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发表时间：
2011-07
期刊：
影响因子：
2.6
通讯作者：
Sperling RA
中科院分区：
文献类型：
--
作者：
Rentz DM;Amariglio RE;Becker JA;Frey M;Olson LE;Frishe K;Carmasin J;Maye JE;Johnson KA;Sperling RA
脑β淀粉样蛋白（a β）沉积发生在相当一部分认知正常（CN）老年人中。然而，使用标准的神经心理学测量方法很难可靠地检测到CN中淀粉样蛋白相关认知改变的证据。我们试图确定高要求的面孔-名字联想记忆测试（FNAME）是否可以检测到与a β相关的CN记忆障碍的证据。我们研究了45例CN患者（平均年龄= 71.7±8.8），临床痴呆评分（CDR）评分= 0,MMSE≥28，使用匹兹堡化合物B （PiB PET）正电子发射断层扫描。记忆因子得分由FNAME名称检索（FN-N）、FNAME职业检索（FN-O）和6项选择性提醒测验（SRT）的主成分分析得出。使用多元线性和逻辑回归分析，我们将记忆因子得分与PiB分布体积比（DVR，小脑参考）联系起来，作为额叶皮质和代表楔前叶、后扣带和侧顶叶皮质（PPCLP）的后皮质区域的连续变量或二分类变量，并与年龄和AMNART智商（认知储备（CR）的代理）共变。FN-N与A - β沉积在额叶（R2 = 0.29, β = - 2.2, p = 0.02）和PPCLP皮层（R2 = 0.26, β = - 2.4, p = 0.05）呈显著负相关。相比之下，FN-O和SRT与Aβ沉积均无显著相关性。在一项要求苛刻的面孔-名字联想记忆测试中的表现与与记忆系统相关的大脑区域的a β负荷有关。老年人对面孔和名字的联想记忆是一种常见的抱怨，可能是早期a β相关损伤的敏感标志。
Cerebral amyloid beta (Aβ) deposition occurs in a substantial fraction of cognitively normal (CN) older individuals. However, it has been difficult to reliably detect evidence of amyloid-related cognitive alterations in CN using standard neuropsychological measures. We sought to determine whether a highly demanding face-name associative memory exam (FNAME) could detect evidence of Aβ-related memory impairment in CN. We studied 45 CN subjects (mean age = 71.7 ± 8.8) with Clinical Dementia Rating (CDR) scores = 0 and MMSE ≥ 28, using Positron Emission Tomography with Pittsburgh Compound B (PiB PET). Memory factor scores were derived from a principal components analysis for FNAME name retrieval (FN-N), FNAME occupation retrieval (FN-O) and the 6-Trial Selective Reminding Test (SRT). Using multiple linear and logistic regression analyses, we related the memory factor scores to PiB distribution volume ratios (DVR, cerebellar reference) as either a continuous or a dichotomous variable in frontal cortex and a posterior cortical region representing the precuneus, posterior cingulate and lateral parietal cortices (PPCLP), co-varying for age and AMNART IQ (a proxy of cognitive reserve (CR)). A significant inverse relationship for FN-N was found with Aβ deposition in frontal (R2 = .29, β = −2.2, p = 0.02) and PPCLP cortices (R2 = .26, β = −2.4, p = 0.05). In contrast, neither FN-O nor the SRT were significantly related to Aβ deposition. Performance on a demanding test of face-name associative memory was related to Aβ burden in brain regions associated with memory systems. Associative memory for faces and names, a common complaint among older adults, may be a sensitive marker of early Aβ-related impairment.
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影响因子：
2.4
作者：
Clare, L;Wilson, BA;Hodges, JR
通讯作者：
Hodges, JR
DOI：
10.1073/pnas.0308627101
发表时间：
2004-03-30
影响因子：
11.1
作者：
Greicius, MD;Srivastava, G;Menon, V
通讯作者：
Menon, V
影响因子：
6.9
作者：
De Jager, CA;Milwain, E;Budge, M
通讯作者：
Budge, M
DOI：
10.1523/jneurosci.3189-09.2009
发表时间：
2009-10-07
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Hedden T;Van Dijk KR;Becker JA;Mehta A;Sperling RA;Johnson KA;Buckner RL
通讯作者：
Buckner RL
影响因子：
--
作者：
Aizenstein, Howard Jay;Nebes, Robert D.;Saxton, Judith A.;Price, Julie C.;Mathis, Chester A.;Tsopelas, Nicholas D.;Ziolko, Scott K.;James, Jeffrey A.;Snitz, Beth E.;Houck, Patricia R.;Bi, Wenzhu;Cohen, Ann D.;Lopresti, Brian J.;DeKosky, Steven T.;Halligan, Edythe M.;Klunk, William E.
通讯作者：
Klunk, William E.