Epidemiology of Infection
Epidemiology of Infection
复制标题
感染流行病学
DOI：
--
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发表时间：
2001
期刊：
影响因子：
--
通讯作者：
H. Mitchell
中科院分区：
文献类型：
--
作者：
H. Mitchell
本章为读者提供了关于幽门螺杆菌流行病学的最新数据，并回顾了目前存在争议的领域。H.幽门螺杆菌感染是普遍存在的，男性和女性都受到感染。自然获得H.幽门螺杆菌感染大多发生在儿童时期。一旦在胃粘膜内建立，细菌就终生存在。H. pylori可能是一种人畜共患病，首先出现在两项血清流行病学研究的出版物之后，这两项研究表明，屠宰场和肉类加工工人的幽门螺杆菌感染率显著高于不从事动物或动物产品加工的受试者。证实了成人-儿童传播的重要性，血清转换仅发生在儿童感染H。幽门螺杆菌阳性的母亲在研究期间。H.幽门螺杆菌感染者的胃液中有高达58%的幽门螺杆菌。幽门螺杆菌增加了反流胃液可能代表该生物体传播媒介的可能性。检测H.来自口腔的幽门螺杆菌特异性DNA变化显著。尝试检测H.通过PCR检测粪便中的幽门螺杆菌DNA会导致不同的结果。根据H.幽门螺杆菌和消化性溃疡疾病、胃癌和B细胞粘膜相关淋巴组织（MALT）淋巴瘤，迫切需要制定干预策略以防止细菌的传播。
This chapter provides the reader with the most recent data in regard to the epidemiology of Helicobacter pylori and reviews current areas of controversy. H. pylori infection is ubiquitous and infects both males and females. Natural acquisition of H. pylori infection occurs, for the most part, in childhood. Once established within the gastric mucosa, the bacterium persists for life. The possibility that H. pylori may be a zoonosis first arose following the publication of two seroepidemiological studies that showed that the prevalence of H. pylori infection in abattoir and meat workers was significantly increased as compared with that in subjects not involved in handling animals or animal products. Confirming the importance of adult-child transmission, seroconversion only occurred among children living with H. pylori-positive mothers over the period of the study. The presence of H. pylori in the gastric juice of up to 58% of patients infected with H. pylori raises the possibility that refluxed gastric juice may represent a vehicle of transmission for the organism. The ability to detect H. pylori-specific DNA from the oral cavity has varied significantly. Attempts to detect H. pylori DNA in feces by PCR have resulted in variable outcomes. Given the association between H. pylori and peptic ulcer disease, gastric cancer, and B-cell mucosa-associated lymphoid tissue (MALT) lymphoma, there is an urgent need for the development of intervention strategies to prevent the spread of the bacterium.
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幽门螺杆菌在常规仔猪中的持续存在。
DOI：
10.1093/infdis/161.6.1299
发表时间：
1990
期刊：
The Journal of infectious diseases
影响因子：
--
作者：
Eaton,KA;Morgan,DR;Krakowka,S
通讯作者：
Krakowka,S
牙科工作人员幽门螺杆菌感染：血清流行病学研究。
DOI：
--
发表时间：
1992
期刊：
The American journal of gastroenterology
影响因子：
--
作者：
Malaty,HM;EvansJr,DJ;Abramovitch,K;Evans,DG;Graham,DY
通讯作者：
Graham,DY
影响因子：
120.7
作者：
Parsonnet, J;Shmuely, H;Haggerty, T
通讯作者：
Haggerty, T
影响因子：
158.5
作者：
PARSONNET, J;HANSEN, S;FRIEDMAN, GD
通讯作者：
FRIEDMAN, GD
影响因子：
29.4
作者：
GRAHAM, DY;MALATY, HM;ADAM, E
通讯作者：
ADAM, E