Role of polygenic and environmental factors in the co-occurrence of depression and psychosis symptoms: a network analysis.
Role of polygenic and environmental factors in the co-occurrence of depression and psychosis symptoms: a network analysis.
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DOI：
10.1038/s41398-022-02022-9
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发表时间：
2022-06-22
影响因子：
6.8
通讯作者：
Barker, Edward D.
中科院分区：
文献类型：
--
作者：
Garcia-Mondragon, Liliana;Konac, Deniz;Newbury, Joanne B.;Young, Katherine S.;Ing, Alex;Furtjes, Anna E.;Barker, Edward D.
抑郁症和精神病通常是共病的;它们也有重叠的遗传和环境风险因素，包括创伤和地区水平的暴露。本研究旨在通过网络方法促进对这种共病的理解，通过（1）识别连接终身抑郁症和精神病症状集群的桥梁节点，以及（2）评估多基因和环境风险因素对这些症状的影响。这项研究包括来自英国生物银行欧洲血统参与者的数据，这是一个基于人群的大样本（N = 77，650）。在步骤1中，网络模型确定了抑郁症和精神病的终身症状与功能障碍之间的桥梁节点。在第二步中，将遗传和环境风险因素结合起来，以检查症状与抑郁症和精神分裂症的多基因风险评分、终生创伤暴露和区域因素（包括剥夺、空气污染和绿地）相关的程度。孤独感、对不真实阴谋的信念、抑郁障碍和精神障碍是抑郁和精神病症状之间的桥梁。抑郁症和精神分裂症的多基因风险评分主要分别与抑郁症和精神病损害相关，而不是与特定症状相关。累积性创伤作为一个桥梁节点出现，将剥夺与无意识的感觉和不真实的阴谋信念联系起来，表明创伤的经历与抑郁症和精神病症状的共同发生密切相关，这些症状与对自己和他人的负面看法有关。这些关键症状和风险因素提供了对抑郁症和精神病终生共同发生的见解。
Depression and psychosis are often comorbid; they also have overlapping genetic and environmental risk factors, including trauma and area-level exposures. The present study aimed to advance understanding of this comorbidity via a network approach, by (1) identifying bridge nodes that connect clusters of lifetime depression and psychosis symptoms and (2) evaluating the influence of polygenic and environmental risk factors in these symptoms. This study included data from European ancestry participants in UK Biobank, a large population-based sample (N = 77,650). In Step 1, a network model identified bridge nodes between lifetime symptoms of depression and psychosis and functional impairment. In Step 2, genetic and environmental risk factors were incorporated to examine the degree to which symptoms associated with polygenic risk scores for depression and schizophrenia, lifetime exposure to trauma and area-level factors (including deprivation, air pollution and greenspace). Feelings of worthlessness, beliefs in unreal conspiracy against oneself, depression impairment and psychosis impairment emerged as bridges between depression and psychosis symptoms. Polygenic risk scores for depression and schizophrenia were predominantly linked with depression and psychosis impairment, respectively, rather than with specific symptoms. Cumulative trauma emerged as a bridge node associating deprivation with feelings of worthlessness and beliefs in unreal conspiracy, indicating that the experience of trauma is prominently linked with the co-occurrence of depression and psychosis symptoms related to negative views of oneself and others. These key symptoms and risk factors provide insights into the lifetime co-occurrence of depression and psychosis.
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影响因子：
6.6
作者：
Gaweda, Lukasz;Pionke, Renata;Frydecka, Dorota
通讯作者：
Frydecka, Dorota
影响因子：
4.4
作者：
Fried EI;van Borkulo CD;Cramer AO;Boschloo L;Schoevers RA;Borsboom D
通讯作者：
Borsboom D
DOI：
10.1093/bioinformatics/btu848
发表时间：
2015-05-01
期刊：
Bioinformatics (Oxford, England)
影响因子：
--
作者：
Euesden J;Lewis CM;O'Reilly PF
通讯作者：
O'Reilly PF
影响因子：
6.7
作者：
Gracie, A.;Freeman, D.;Fowler, D.
通讯作者：
Fowler, D.
DOI：
10.1177/1524838013515758
发表时间：
2015-01
期刊：
Trauma, violence & abuse
影响因子：
--
作者：
Beyer K;Wallis AB;Hamberger LK
通讯作者：
Hamberger LK