Effects of airborne fine particles (PM2.5 ) on deep vein thrombosis admissions in the northeastern United States.
Effects of airborne fine particles (PM2.5 ) on deep vein thrombosis admissions in the northeastern United States.
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DOI：
10.1111/jth.12873
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发表时间：
2015-05
期刊：
影响因子：
--
通讯作者：
Schwartz J
中科院分区：
文献类型：
--
作者：
Kloog I;Zanobetti A;Nordio F;Coull BA;Baccarelli AA;Schwartz J
尽管存在生物相容性，但与空气污染暴露导致DVT和肺栓塞（PE）相关的文献很少。迄今为止，尚未发表任何全面的研究，检查短期和长期暴露于颗粒物（PM）2.5与DVT或PE之间的关联。使用新型PM2.5预测模型，我们研究了长期和短期PM2.5暴露是否与美国东北部老年人的深静脉血栓形成和肺栓塞入院有关。我们估计了每个邮政编码的PM2.5日暴露量。我们调查了PM2.5对DVT和PE住院的长期和短期影响。研究中有453，413例DVT和151，829例PE入院。对于短期暴露，我们进行了月和年的病例交叉分析，并将危险期定义为滞后01（入院当天和前一天的暴露）。对于长期关联，我们使用Poisson回归。短期暴露增加10 µg/m3与DVT入院增加0.63%（95% CI = 0.03 - 1.25）和长期暴露入院增加6.98%（95% CI = 5.65 - 8.33）相关。对于PE，相关风险分别为0.38（95% CI =-0.68至1.25）和2.67%（95% CI = 5.65至8.33）。当分析仅限于符合现行EPA年度标准12 μg/m3的地点时，这些结果仍然存在。我们的研究结果表明，PM2.5暴露与DVT和PE住院有关，目前的标准对这一结果没有保护作用。
Literature relating air pollution exposure to DVT and pulmonary embolism (PE), in spite of biological plausibility, is sparse. No comprehensive study examining associations between both short and long term exposure to Particulate matter (PM)2.5 and DVT or PE has been published to date. Using a novel PM2.5 prediction model we study whether long and short term PM2.5 exposure is associated with DVT and PE admissions among elderly across the northeastern USA. We estimated daily exposure of PM2.5 in each zipcode. We investigated long and short-term effects of PM2.5 on DVT and PE hospital admissions. There were 453,413 DVT and 151,829 PE admissions in the study. For short term exposure, we performed a case crossover analysis matching on month and year and defined the hazard period as lag 01 (exposure of day of admission and previous day). For the long term association, we used a Poisson regression. A 10-µg/m3 increase in short term exposure was associated with a 0.63 % increase in DVT admissions (95% CI = 0.03 to 1.25) and a 6.98 % (95% CI = 5.65 to 8.33) increase in long term exposure admissions. For PE, the associated risks were 0.38 (95% CI = −0.68 to 1.25) and 2.67 % (95% CI = 5.65 to 8.33). These results persisted when analyses were restricted to location-periods meeting the current EPA annual standard of 12-µg/m3. Our findings showed that PM2.5 exposure was associated with DVT and PE hospital admissions, and that current standards are not protective of this result.
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影响因子：
11.4
作者：
Kloog I;Nordio F;Coull BA;Schwartz J
通讯作者：
Schwartz J
DOI：
10.1186/1476-069x-11-40
发表时间：
2012-06-18
期刊：
Environmental health : a global access science source
影响因子：
--
作者：
Kloog I;Melly SJ;Ridgway WL;Coull BA;Schwartz J
通讯作者：
Schwartz J
影响因子：
24.3
作者：
Fusco, D;Forastiere, F;Perucci, CA
通讯作者：
Perucci, CA
影响因子：
10.4
作者：
Dales, R. E.;Cakmak, S.;Vidal, C. B.
通讯作者：
Vidal, C. B.
影响因子：
5.4
作者：
Levy, D;Lumley, T;Checkoway, H
通讯作者：
Checkoway, H