Signal Integration by Cyclin-Dependent Kinase 8 (CDK8) Module and Other Mediator Subunits in Biotic and Abiotic Stress Responses.
Signal Integration by Cyclin-Dependent Kinase 8 (CDK8) Module and Other Mediator Subunits in Biotic and Abiotic Stress Responses.
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生物和非生物应激反应中细胞周期蛋白依赖性激酶 8 (CDK8) 模块和其他介导亚基的信号整合
DOI：
10.3390/ijms22010354
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发表时间：
2020-12-31
影响因子：
5.6
通讯作者：
Zhu Y
中科院分区：
文献类型：
--
作者：
Chong L;Shi X;Zhu Y
环境压力促使植物发展出各种机制来适应恶劣的条件。广泛的研究表明，植物转录组对生物和非生物胁迫的反应发生了显著的重编程。真核生物中高度保守的大分子多亚基转录共激活因子，被称为Mediator，在帮助植物响应环境干扰的重要基因的调控中发挥着重要作用。CDK8模块是介体复合体中一个相对较新的成分，已被证明有助于植物的防御、发育和逆境反应。以往的研究表明，CDK8模块主要通过可逆地与核心介体结合，在真核细胞中作为转录抑制因子发挥作用。然而，越来越多的证据表明，根据生物和非生物胁迫的类型，CDK8模块可能发挥着截然不同的调节作用。本文将对CDK8模块以及其他已报道的在胁迫条件下植物细胞信号转导中的介体亚单位的研究现状进行综述。
Environmental stresses have driven plants to develop various mechanisms to acclimate in adverse conditions. Extensive studies have demonstrated that a significant reprogramming occurs in the plant transcriptome in response to biotic and abiotic stresses. The highly conserved and large multi-subunit transcriptional co-activator of eukaryotes, known as the Mediator, has been reported to play a substantial role in the regulation of important genes that help plants respond to environmental perturbances. CDK8 module is a relatively new component of the Mediator complex that has been shown to contribute to plants’ defense, development, and stress responses. Previous studies reported that CDK8 module predominantly acts as a transcriptional repressor in eukaryotic cells by reversibly associating with core Mediator. However, growing evidence has demonstrated that depending on the type of biotic and abiotic stress, the CDK8 module may perform a contrasting regulatory role. This review will summarize the current knowledge of CDK8 module as well as other previously documented Mediator subunits in plant cell signaling under stress conditions.
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