TSPO protein binding partners in bacteria, animals, and plants.
TSPO protein binding partners in bacteria, animals, and plants.
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DOI：
10.1007/s10863-021-09905-4
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发表时间：
2021-08
影响因子：
3
通讯作者：
Ferguson-Miller S
中科院分区：
文献类型：
--
作者：
Hiser C;Montgomery BL;Ferguson-Miller S
古老的膜蛋白TSPO在古细菌、细菌、昆虫、脊椎动物、植物和真菌中广泛分布。TSPO的一级氨基酸序列在不同物种之间仅适度保守，尽管其五个跨膜螺旋结构似乎主要保守。据报道，其在细胞膜中的位置和方向在物种和组织之间存在差异，这对潜在的不同结合伴侣和功能产生了影响。大多数TSPO功能与应激诱导的代谢变化有关，但在许多情况下，TSPO本身是如何发挥作用的尚不清楚--是作为受体、传感器、转运蛋白还是转运蛋白。许多证据表明，TSPO通过与各种蛋白质结合伴侣或与内源性或外源性配体缔合而间接起作用。在这篇综述中，我们专注于蛋白质，最常被调用作为TSPO结合伙伴。我们认为，TSPO最初是一种细菌受体/压力传感器与卟啉结合作为其最古老的功能，它后来开发了额外的压力相关的作用，在真核生物中，其能力结合新的合作伙伴进化。
The ancient membrane protein TSPO is phylogenetically widespread from archaea and bacteria to insects, vertebrates, plants, and fungi. TSPO’s primary amino acid sequence is only modestly conserved between diverse species, although its five transmembrane helical structure appears mainly conserved. Its cellular location and orientation in membranes have been reported to vary between species and tissues, with implications for potential diverse binding partners and function. Most TSPO functions relate to stress-induced changes in metabolism, but in many cases it is unclear how TSPO itself functions—whether as a receptor, a sensor, a transporter, or a translocator. Much evidence suggests that TSPO acts indirectly by association with various protein binding partners or with endogenous or exogenous ligands. In this review, we focus on proteins that have most commonly been invoked as TSPO binding partners. We suggest that TSPO was originally a bacterial receptor/stress sensor associated with porphyrin binding as its most ancestral function and that it later developed additional stress-related roles in eukaryotes as its ability to bind new partners evolved.
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影响因子：
4.1
作者：
Batarseh, Amani;Papadopoulos, Vassilios
通讯作者：
Papadopoulos, Vassilios
DOI：
10.1016/j.biocel.2013.03.004
发表时间：
2013-07-01
影响因子：
4
作者：
Austin, Christopher J. D.;Kahlert, Jan;Rendina, Louis M.
通讯作者：
Rendina, Louis M.
DOI：
10.1074/jbc.m709221200
发表时间：
2008-04-04
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Bose M;Whittal RM;Miller WL;Bose HS
通讯作者：
Bose HS
影响因子：
5.3
作者：
Balsemão-Pires E;Jaillais Y;Olson BJ;Andrade LR;Umen JG;Chory J;Sachetto-Martins G
通讯作者：
Sachetto-Martins G
影响因子：
4
作者：
Azarashvili, Tamara;Grachev, Dmitry;Reiser, Georg
通讯作者：
Reiser, Georg