Methods for assessing cough sensitivity.
Methods for assessing cough sensitivity.
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评估咳嗽敏感性的方法
DOI：
10.21037/jtd-2020-icc-005
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发表时间：
2020-09
影响因子：
2.5
通讯作者：
Lai K
中科院分区：
文献类型：
--
作者：
Mai Y;Fang L;Zhong S;de Silva SDSH;Chen R;Lai K
咳嗽敏感性可以描述为咳嗽反射对不同刺激的反应强度，这些刺激激活化学和机械敏感的迷走神经传入神经，支配气道和肺部。咳嗽反射敏感性的测量对于揭示咳嗽的潜在机制和评估药物干预的效果具有重要作用。此外，对咳嗽抑制疗法的不同反应表明咳嗽过敏的存在。考虑到上述这些因素，因此应通过各种咳嗽激发试验来评估咳嗽敏感性。根据咳嗽反射的神经解剖学特征，开发了化学激发试验来客观评估咳嗽敏感性。在咳嗽吸入挑战中，辣椒素和柠檬酸通常用作诱发咳嗽的咳嗽剂，经验证可描述咳嗽对化学刺激物的敏感性。最近，还尝试了机械方法来测量咳嗽反射的机械敏感性。在临床试验中采用咳嗽挑战时，方法学上的考虑和选择对于合理评估咳嗽敏感性是必要的。因此，在这篇综述中，我们将重点描述咳嗽敏感性测量的各种方法，并详细说明影响实验诱导咳嗽结果准确性的一些因素。
Cough sensitivity can be described as the reaction intensity of the cough reflex to different stimuli which activate chemically and mechanically sensitive vagal afferent nerves innervating airways and lungs. Measurement of cough reflex sensitivity plays an important role in revealing the underlying mechanisms of cough and evaluating the effects of pharmacological interventions. Besides, different responses to cough suppression therapies indicate the existence of cough hypersensitivity. In consideration of these factors stated above, cough sensitivity should therefore be assessed with a variety of cough challenge tests. Based on the neuroanatomical characteristics of the cough reflex, chemical challenge tests have been developed to objectively assess cough sensitivity. In cough inhalation challenges, capsaicin and citric acid are commonly used as the tussive agents to induce cough, which are validated for describing a profile of cough sensitivity to chemical irritants. Recently, mechanical methodologies have also been tried to measure the mechanical sensitivity of the cough reflex. Methodological consideration and selection are necessary for the reasonable assessment of cough sensitivity while employing cough challenges in clinical trials. Thus, in this review, we will focus on describing various methodologies of cough sensitivity measurement and, detailing some factors influencing on the accuracy of outcomes in the experimentally induced cough.
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影响因子：
1.4
作者：
BLOUSTINE, S;LANGSTON, L;MILLER, T
通讯作者：
MILLER, T
DOI：
10.1186/1745-9974-8-12
发表时间：
2012-12-12
期刊：
Cough (London, England)
影响因子：
--
作者：
Barton A;Gaydecki P;Holt K;Smith JA
通讯作者：
Smith JA
影响因子：
8.8
作者：
CHENEY, FW;BUTLER, J
通讯作者：
BUTLER, J
影响因子：
3.2
作者：
Dicpinigaitis, Peter V.;Tibb, Amit S.;Poore, Cathy L.
通讯作者：
Poore, Cathy L.
影响因子：
10
作者：
Decalmer, Samantha Clare;Webster, Deborah;Smith, Jaclyn Ann
通讯作者：
Smith, Jaclyn Ann