Multiple irradiation sensing of the optical effective attenuation coefficient for spectral correction in handheld OA imaging.
Multiple irradiation sensing of the optical effective attenuation coefficient for spectral correction in handheld OA imaging.
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DOI：
10.1016/j.pacs.2016.05.004
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发表时间：
2016-06
期刊：
影响因子：
7.9
通讯作者：
Akarcay, H. Gunhan
中科院分区：
文献类型：
--
作者：
Held, K. Gerrit;Jaeger, Michael;Ricka, Jaro;Frenz, Martin;Akarcay, H. Gunhan
关键词：
光谱光声（OA）成像能够基于含氧和脱氧血液的不同光学吸收光谱来实现血氧水平的空间分辨测量。然而，大块组织中的波长相关光学衰减使所获取的OA光谱失真，从而使定量氧合测量具有挑战性。我们证明了这种光谱失真的校正，而不需要先验知识的组织的光学特性，使用的概念，多个照射感测：记录OA信号振幅的吸收结构（例如血管），这作为一个内在的通量检测器，作为辐射位置的函数。这允许体有效光学衰减系数μeff，λ的重建。如果在各种照射波长下进行，则实现了对波长相关的通量衰减的校正，从而揭示了吸收结构上的准确光谱信息。进行了体模研究，以显示该技术用于手持临床OA和超声成像的潜力。
Spectral optoacoustic (OA) imaging enables spatially-resolved measurement of blood oxygenation levels, based on the distinct optical absorption spectra of oxygenated and de-oxygenated blood. Wavelength-dependent optical attenuation in the bulk tissue, however, distorts the acquired OA spectrum and thus makes quantitative oxygenation measurements challenging. We demonstrate a correction for this spectral distortion without requiring a priori knowledge of the tissue optical properties, using the concept of multiple irradiation sensing: recording the OA signal amplitude of an absorbing structure (e.g. blood vessel), which serves as an intrinsic fluence detector, as function of irradiation position. This permits the reconstruction of the bulk effective optical attenuation coefficient μeff,λ. If performed at various irradiation wavelengths, a correction for the wavelength-dependent fluence attenuation is achieved, revealing accurate spectral information on the absorbing structures. Phantom studies were performed to show the potential of this technique for handheld clinical combined OA and ultrasound imaging.
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