The effects of acupuncture treatment on the right frontoparietal network in migraine without aura patients.
The effects of acupuncture treatment on the right frontoparietal network in migraine without aura patients.
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DOI：
10.1186/s10194-015-0518-4
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发表时间：
2015
期刊：
影响因子：
--
通讯作者：
Zou Y
中科院分区：
文献类型：
--
作者：
Li K;Zhang Y;Ning Y;Zhang H;Liu H;Fu C;Ren Y;Zou Y
偏头痛患者静息态脑网络的功能和结构异常已被先前的功能性磁共振成像（fMRI）研究证实。然而，很少有研究集中在治疗偏头痛的神经反应进行了治疗。在这项研究中，我们试图检查标准针灸治疗偏头痛患者的右额顶网络（RFPN）的治疗相关的影响。共招募了12名无先兆偏头痛（MWoA）患者进行静息态fMRI扫描，并在标准针刺治疗4周后重新扫描。另取12例健康对照者进行一次扫描比较。我们分析了治疗前MWoA患者和HC受试者之间以及MWoA患者治疗前后RFPN的功能连接。还进行了扩散张量图像（DTI）数据分析，以检测纤维相关的治疗反应。我们观察到RFPN的FC显著降低，并且可以通过针刺治疗来逆转FC降低。MWoA患者治疗后FC的变化与视觉模拟评分（VAS）评分的下降呈负相关。这项研究表明，针刺治疗MWoA患者与RFPN的内在FC下降的正常化效应相关。我们的研究为MWoA患者的治疗相关神经反应提供了新的见解，并为MWoA患者的治疗评估提出了潜在的功能途径。进一步的研究仍需证实目前的结果，并阐明针灸治疗的复杂神经机制。
Functional and structural abnormalities in resting-state brain networks in migraine patients have been confirmed by previous functional magnetic resonance imaging (fMRI) studies. However, few studies focusing on the neural responses of therapeutic treatment on migraine have been conducted. In this study, we tried to examined the treatment-related effects of standard acupuncture treatment on the right frontoparietal network (RFPN) in migraine patients. A total of 12 migraine without aura (MWoA) patients were recruited to undergo resting-state fMRI scanning and were rescanned after 4 weeks standard acupuncture treatment. Another 12 matched healthy control (HC) subjects underwent once scanning for comparison. We analyzed the functional connectivity of the RFPN between MWoA patients and HC subjects before treatment and that of the MWoA patients before and after treatment. Diffusion tensor images (DTI) data analyzing was also performed to detect fiber-related treatment responses. We observed significantly decreased FC in the RFPN and that the decreased FC could be reversed by acupuncture treatment. The changes of FC in MWoA patients was negatively correlated with the decrease of visual analogue scale (VAS) scores after treatment. This study indicated that acupuncture treatment for MWoA patients was associated with normalizing effects on the intrinsic decreased FC of the RFPN. Our study provided new insights into the treatment-related neural responses in MWoA patients and suggested potential functional pathways for the evaluation of treatment in MWoA patients. Future studies are still in need to confirm the current results and to elucidate the complex neural mechanisms of acupuncture treatment.
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