Altered functional connectivity of cognitive-related cerebellar subregions in well-recovered stroke patients.
Altered functional connectivity of cognitive-related cerebellar subregions in well-recovered stroke patients.
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DOI：
10.1155/2013/452439
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发表时间：
2013
影响因子：
3.1
通讯作者：
Yu C
中科院分区：
文献类型：
--
作者：
Li W;Han T;Qin W;Zhang J;Liu H;Li Y;Meng L;Ji X;Yu C
小脑包含几个与认知相关的子区域，它们参与不同的功能网络。小脑的小脑顶II与额顶网络（FPN）相关，而小脑IX与默认模式网络（DMN）相关。这两个神经网络相互关联，共同参与认知控制，可能促进脑卒中患者的运动恢复。在本研究中，我们的目的是调查静息状态功能连接（rsFC）的变化，在25个皮质下缺血性中风患者的整体运动功能恢复良好。与先前的研究一致，小脑IX与FPN相关，包括背外侧前额叶皮层（DLPFC）和后顶叶皮层，小脑IX与DMN相关，包括后扣带皮层/楔前叶（PCC/Pcu），内侧前额叶皮层（MPFC），DLPFC，外侧顶叶皮层和前颞叶皮层。脑卒中患者小脑各亚区的rsFC均无明显增加，提示认知相关亚区的rsFC不是脑卒中患者运动功能恢复的关键因素。小脑相关的认知控制网络的断开可能解释了即使在整体运动功能恢复良好的脑卒中患者中认知控制功能的缺陷。
The cerebellum contains several cognitive-related subregions that are involved in different functional networks. The cerebellar crus II is correlated with the frontoparietal network (FPN), whereas the cerebellar IX is associated with the default-mode network (DMN). These two networks are anticorrelated and cooperatively implicated in cognitive control, which may facilitate the motor recovery in stroke patients. In the present study, we aimed to investigate the resting-state functional connectivity (rsFC) changes in 25 subcortical ischemic stroke patients with well-recovered global motor function. Consistent with previous studies, the crus II was correlated with the FPN, including the dorsolateral prefrontal cortex (DLPFC) and posterior parietal cortex, and the cerebellar IX was correlated with the DMN, including the posterior cingulate cortex/precuneus (PCC/Pcu), medial prefrontal cortex (MPFC), DLPFC, lateral parietal cortices, and anterior temporal cortices. No significantly increased rsFCs of these cerebellar subregions were found in stroke patients, suggesting that the rsFCs of the cognitive-related cerebellar subregions are not the critical factors contributing to the recovery of motor function in stroke patients. The finding of the disconnection in the cerebellar-related cognitive control networks may possibly explain the deficits in cognitive control function even in stroke patients with well-recovered global motor function.
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DOI：
10.1073/pnas.0504136102
发表时间：
2005-07-05
影响因子：
11.1
作者：
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影响因子：
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