Immunoglobulin G antibody response to the Sputnik V vaccine: previous SARS-CoV-2 seropositive individuals may need just one vaccine dose.
Immunoglobulin G antibody response to the Sputnik V vaccine: previous SARS-CoV-2 seropositive individuals may need just one vaccine dose.
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DOI：
10.1016/j.ijid.2021.07.070
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发表时间：
2021-10
期刊：
影响因子：
--
通讯作者：
de Waard JH
中科院分区：
文献类型：
--
作者：
Claro F;Silva D;Rodriguez M;Rangel HR;de Waard JH
简介：我们评估了免疫球蛋白（IG）G抗体对核衣壳蛋白（NP）和受体结合结构域（RBD）的刺突蛋白的SARS-CoV-2在委内瑞拉的一个队列的86个人，之前和之后接受Sputnik V疫苗。研究方法：针对NP和RBD的抗体应答用酶联免疫吸附测定法在接种疫苗之前、第一剂疫苗之后3周和第二剂疫苗之后6周测定。结果：接种前，59人为NP和/或RBD血清阴性，27人血清阳性。在血清阴性队列中，42%在第一次接种疫苗后没有产生针对RBD的IgG免疫应答，但100%在2次接种后产生强烈的IgG应答。所有血清阳性个体在第一剂疫苗接种后均产生了针对RBD的强烈IgG抗体应答，抗体水平比接受2剂疫苗接种的血清阴性个体高出约40%。先前血清阳性的受试者在第二次疫苗接种后，对RBD的IgG抗体应答没有显著增加。结论：我们证明了2剂Sputnik V疫苗在所有研究个体中引发了抗体应答。第二次Sputnik V剂量对接种前SARS-CoV-2抗原血清阳性者的IgG应答没有影响。
Introduction: We evaluated the immunoglobulin (Ig) G antibody response against the nucleocapsid protein (NP) and the receptor-binding domain (RBD) of the spike protein of SARS-CoV-2 in a cohort of 86 individuals in Venezuela, before and after receiving the Sputnik V vaccine. Methods: Antibody responses against NP and RBD were determined with an enzyme-linked immunosorbent assay just before, 3 weeks after the first, and 6 weeks after the second dose of the vaccine. Results: Before vaccination, 59 individuals were seronegative, and 27 seropositive for NP and/or RBD. Of the seronegative cohort, 42% did not develop an IgG immune response against RBD after the first vaccine dose, but 100% had a strong IgG response after 2 doses. All seropositive individuals developed a strong IgG antibody response against RBD after the first vaccine dose, with antibody levels ∼40% higher than seronegative individuals who had received 2 doses. Previously seropositive subjects showed no significant increase in IgG antibody response against RBD after the second vaccine dose. Conclusions: We demonstrate that 2 doses of the Sputnik V vaccine triggered antibody response in all study individuals. The second Sputnik V dose had no impact on IgG response for those seropositive for SARS-CoV-2 antigens before vaccination.
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DOI：
10.1016/j.ijid.2021.05.034
发表时间：
2021-07
期刊：
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases
影响因子：
--
作者：
Sasikala M;Shashidhar J;Deepika G;Ravikanth V;Krishna VV;Sadhana Y;Pragathi K;Reddy DN
通讯作者：
Reddy DN
影响因子：
82.9
作者：
Ebinger JE;Fert-Bober J;Printsev I;Wu M;Sun N;Prostko JC;Frias EC;Stewart JL;Van Eyk JE;Braun JG;Cheng S;Sobhani K
通讯作者：
Sobhani K
DOI：
10.1016/s0140-6736(21)00191-4
发表时间：
2021-02-20
期刊：
Lancet (London, England)
影响因子：
--
作者：
Jones I;Roy P
通讯作者：
Roy P
DOI：
10.1159/000509143
发表时间：
2020-07-01
影响因子：
1.3
作者：
Haehner, Antje;Draf, Julia;Hummel, Thomas
通讯作者：
Hummel, Thomas
影响因子：
168.9
作者：
Pollan, Marina;Perez-Gomez, Beatriz;Yotti, Raquel
通讯作者：
Yotti, Raquel