Dynamic epithelia of the developing vertebrate face.

Dynamic epithelia of the developing vertebrate face.
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DOI:
10.1016/j.gde.2015.02.003
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发表时间:
2015-06
影响因子:
4
通讯作者:
Crump, J. Gage
Crump, J. Gage
中科院分区:
生物学2区
文献类型:
--
作者:
Choe, Chong Pyo;Crump, J. Gage

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一系列节段性的内胚层来源的小袋和外胚层来源的裂隙上皮细胞作为发育中的面部的信号中心。因此,它们精确的形态发生对于脊椎动物头部的正确模式至关重要。细胞间粘附和极性在发育中的面部上皮细胞内是高度动态的,来自相邻间充质的信号控制上皮特征和定向迁移。内胚层和外胚层上皮细胞融合形成初级口和鳃裂,这涉及基底膜溶解、细胞嵌入和凋亡,以及经历进一步的形态发生以产生中耳腔和颈部腺体。最近的面部上皮研究揭示了上皮形态发生的核心程序和对脊椎动物头部协调组装的见解。
A segmental series of endoderm-derived pouch and ectoderm-derived cleft epithelia act as signaling centers in the developing face. Their precise morphogenesis is therefore essential for proper patterning of the vertebrate head. Intercellular adhesion and polarity are highly dynamic within developing facial epithelial cells, with signaling from the adjacent mesenchyme controlling both epithelial character and directional migration. Endodermal and ectodermal epithelia fuse to form the primary mouth and gill slits, which involves basement membrane dissolution, cell intercalations, and apoptosis, as well as undergo further morphogenesis to generate the middle ear cavity and glands of the neck. Recent studies of facial epithelia are revealing both core programs of epithelial morphogenesis and insights into the coordinated assembly of the vertebrate head.
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