Spinal V1 neurons inhibit motor targets locally and sensory targets distally.
Spinal V1 neurons inhibit motor targets locally and sensory targets distally.
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DOI：
10.1016/j.cub.2021.06.053
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发表时间：
2021-09-13
期刊：
影响因子：
--
通讯作者：
Bagnall MW
中科院分区：
文献类型：
--
作者：
Sengupta M;Daliparthi V;Roussel Y;Bui TV;Bagnall MW
脊椎运动输出的吻尾协调对于运动是必不可少的。大多数脊髓中间神经元纵向投射轴突来控制运动输出，但它们沿这一轴的连接性仍不清楚。在这项研究中，我们使用斑马鱼幼体来定位一个主要的抑制群体，V1(Eng1+)神经元的突触输出，这些神经元与双重感觉和运动功能有关。我们发现，V1神经元表现出平均6个脊髓节段沿吻侧和排他侧延伸的长轴突；然而，它们并不沿着整个轴突长度与突触后靶点均匀连接。在局部，V1神经元抑制运动神经元(包括快和慢)和其他运动前靶点，包括V2a、V2b和连合前运动神经元。相比之下，V1神经元与背角感觉群--连合初级上升神经元(COPA)--进行强大的长距离抑制性接触。在同侧脊髓网络的计算模型中，我们表明这种对运动和前运动神经元的短程V1抑制模式是爆发式终止的基础，这对运动波的协调嘴-尾部传播至关重要。我们得出结论，脊髓纵轴上的网络结构可以有很大的不同，局部和远端的连接目标不同，从而产生重要的功能后果。神经元连接的结构是发挥功能的关键。在这项研究中，Sengupta等人。结果表明，脊髓V1神经元在纵轴方向上表现出与其感觉和运动突触后目标的不同连接，并且这种抑制模式对运动行为至关重要。
Rostro-caudal coordination of spinal motor output is essential for locomotion. Most spinal interneurons project axons longitudinally to govern locomotor output, yet their connectivity along this axis remains unclear. In this study, we use larval zebrafish to map synaptic outputs of a major inhibitory population, V1 (Eng1+) neurons, which are implicated in dual sensory and motor functions. We find that V1 neurons exhibit long axons extending rostrally and exclusively ipsilaterally for an average of 6 spinal segments; however, they do not connect uniformly with their post-synaptic targets along the entire length of their axon. Locally, V1 neurons inhibit motor neurons (both fast and slow) and other premotor targets including V2a, V2b and commissural pre-motor neurons. In contrast, V1 neurons make robust long-range inhibitory contacts onto a dorsal horn sensory population, the Commissural Primary Ascending neurons (CoPAs). In a computational model of the ipsilateral spinal network, we show that this pattern of short range V1 inhibition to motor and premotor neurons underlies burst termination, which is critical for coordinated rostro-caudal propagation of the locomotor wave. We conclude that spinal network architecture in the longitudinal axis can vary dramatically, with differentially targeted local and distal connections, yielding important consequences for function. The structure of neuronal connectivity is key to function. In this study, Sengupta et al. show that spinal V1 neurons exhibit differential connectivity to their sensory and motor post synaptic targets in the longitudinal axis and that this pattern of inhibition is critical for locomotor behavior.
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