The myofibroblast: phenotypic characterization as a prerequisite to understanding its functions in translational medicine.
The myofibroblast: phenotypic characterization as a prerequisite to understanding its functions in translational medicine.
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DOI：
10.1111/j.1582-4934.2007.00213.x
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发表时间：
2008-01
影响因子：
5.3
通讯作者：
Eyden B
中科院分区：
文献类型：
--
作者：
Eyden B
“转化研究”一词传达了追求人类疾病治疗应用的理念。长期以来，肌成纤维细胞因在伤口愈合中发挥作用以及在纤维化病症和肿瘤基质中的存在而闻名，它正在成为转化研究的焦点，尤其是通过越来越多地记录其作为肿瘤促进细胞的作用。在纤维增殖性疾病、癌症和组织工程中，肌成纤维细胞衍生 部分可能来自循环骨髓源性细胞和上皮间质转化，正在引起人们的极大关注。在癌症中，这种细胞最初被认为是肿瘤扩散的屏障，但现在越来越多的证据表明它是肿瘤进展的积极参与者。而肌成纤维细胞参与这些病理过程正在将肌成纤维细胞推向众人瞩目。 尽管将转化医学作为潜在的抗纤维化和抗癌治疗的目标，但文献中仍然有许多迹象表明肌成纤维细胞是一种对其分化知之甚少的细胞。部分原因是未能认识到电子显微镜对理解这种细胞性质的贡献。因此，本文致力于详细介绍肌成纤维细胞的主要表型特征，并促进肌成纤维细胞的研究。 该论点认为，对肌成纤维细胞如何在正常生物和病理过程中发挥其作用的理解将通过对其细胞分化的深入了解而得到加强，而细胞分化又可能需要大量的超微结构输入。
The phrase ‘translational research’conveys the idea of the pursuit of applications for the treatment of human disease.The myofibroblast, long known for having a role in wound-healing, and for its presence in fibrotic conditions and tumour stroma, is becoming a focus for translational research, not least through its increasingly documented role as a tumour-promoting cell.In fibroproliferative conditions, cancer and tissue engineering, the myofibroblast, derived partly and possibly from circulating bone-marrow-derived cells and epithelial-to-mesenchymal transformation, is attracting great attention.In cancer, this cell was initially regarded as a barrier to tumour dissemination, but there is now a growing body of evidence to indicate that it is an active participant in tumour progression.While the involvement of the myofibroblast in these pathological processes is pushing the myofibroblast into the limelight of translational medicine as a target for potential anti-fibrotic and anti-cancer therapy, there are still numerous indications from the literature that the myofibroblast is a poorly understood cell in terms of its differentiation.Partly, this is due to a failure to appreciate the contribution of electron microscopy to understanding the nature of this cell.This paper, therefore, is devoted to detailing the principal phenotypic characteristics of the myofibroblast and promotes the argument that understanding how the myofibroblast carries out its roles in normal biological and in pathological processes will be enhanced by a sound understanding of its cellular differentiation, which in turn arguably demands a significant ultrastructural input.
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影响因子：
37.8
作者：
Bentzon, Jacob F.;Sondergaard, Claus S.;Falk, Erling
通讯作者：
Falk, Erling
DOI：
10.1111/j.1471-0528.2004.00469.x
发表时间：
2004-12-01
影响因子：
5.8
作者：
Blyweert, W;Van der Aa, F;De Ridder, D
通讯作者：
De Ridder, D
影响因子：
0.7
作者：
Desmoulière, A;Guyot, C;Gabbiani, C
通讯作者：
Gabbiani, C
影响因子：
5
作者：
BERNDT, A;KOSMEHL, H;TAUCHMANN, V
通讯作者：
TAUCHMANN, V
影响因子：
11.2
作者：
Direkze, NC;Hodivala-Dilke, K;Wright, NA
通讯作者：
Wright, NA