Assessment of the lung microstructure in patients with asthma using hyperpolarized 3He diffusion MRI at two time scales: comparison with healthy subjects and patients with COPD.
Assessment of the lung microstructure in patients with asthma using hyperpolarized 3He diffusion MRI at two time scales: comparison with healthy subjects and patients with COPD.
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DOI：
10.1002/jmri.21408
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发表时间：
2008-07
期刊：
影响因子：
--
通讯作者：
de Lange EE
中科院分区：
文献类型：
--
作者：
Wang C;Altes TA;Mugler JP 3rd;Miller GW;Ruppert K;Mata JF;Cates GD Jr;Borish L;de Lange EE
研究哮喘患者的短时间和长时间尺度3 He扩散。开发了一种混合MRI序列，以在单次屏气期间获得共同配准的短时间尺度和长时间尺度ADC图。研究组：哮喘（n=14）;健康（n=14）; COPD（n=9）。在两个时间尺度和肺量测定法下，在平均ADC和%ADC-abn（ADC>健康的平均值+2SD的%像素）之间建立相关性。使用ROC分析确定敏感性。对于哮喘患者，短时间尺度和长时间尺度组平均ADC分别为0.254±0.032 cm 2/s和0.0237±0.0055 cm 2/s，与健康组相比分别增加了9%和27%（p=0.038和p=0.005）。组平均%ADC-abn分别为6.4%±3.7%和17.5%± 14.2%，分别增加107%和272%（p=0.004和p=0.006）。对于COPD，观察到更大的升高。%ADC-abn比平均ADC在哮喘和健康受试者之间提供更好的区分。在哮喘患者中，ADC与肺量测定无关。用长时间尺度的3 He扩散磁共振成像（MRI）的肺微结构的变化，检测到哮喘，更明显的区域比在短时间尺度。混合扩散法是一种识别小气道疾病的新方法。
To investigate short- and long-time-scale 3He diffusion in asthma. A hybrid MRI sequence was developed to obtain co-registered short- and long-time-scale ADC maps during a single breath-hold. Study groups: asthma (n=14); healthy (n=14); COPD (n=9). Correlations were made between mean-ADC and %ADC-abn (%pixels with ADC>mean+2SD of healthy) at both time-scales, and spirometry. Sensitivities were determined using ROC analysis. For asthmatics, the short- and long-time-scale group-mean ADC were 0.254±0.032 cm2/s and 0.0237±0.0055 cm2/s, respectively, representing a 9% and 27% (p=0.038 and p=0.005) increase compared to healthy group. The group-mean %ADC-abn were 6.4%±3.7% and 17.5%±14.2%, representing a 107% and 272% (p=0.004 and p=0.006) increase. For COPD much greater elevations were observed. %ADC-abn provided better discrimination than mean-ADC between asthmatic and healthy subjects. In asthmatics ADC did not correlate with spirometry. With long-time-scale 3He diffusion magnetic resonance imaging (MRI) changes in lung microstructure were detected in asthma that were more conspicuous regionally than at the short time scale. The hybrid diffusion method is a novel means of identifying small airway disease.
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