Intracellular immune sensing promotes inflammation via gasdermin D-driven release of a lectin alarmin.
Intracellular immune sensing promotes inflammation via gasdermin D-driven release of a lectin alarmin.
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细胞内免疫感应通过气皮蛋白d驱动的凝集素警报素的释放促进炎症。
DOI：
10.1038/s41590-020-00844-7
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发表时间：
2021-03
影响因子：
30.5
通讯作者：
Rathinam VA
中科院分区：
文献类型：
--
作者：
Russo AJ;Vasudevan SO;Méndez-Huergo SP;Kumari P;Menoret A;Duduskar S;Wang C;Pérez Sáez JM;Fettis MM;Li C;Liu R;Wanchoo A;Chandiran K;Ruan J;Vanaja SK;Bauer M;Sponholz C;Hudalla GA;Vella AT;Zhou B;Deshmukh SD;Rabinovich GA;Rathinam VA
Inflammatory caspase sensing of cytosolic lipopolysaccharide (LPS) triggers pyroptosis and the concurrent release of damage-associated molecular patterns (DAMPs). Collectively, DAMPs are key determinants that shape the aftermath of inflammatory cell death. However, the identity and function of the individual DAMPs released are poorly defined. Our proteomics study revealed that cytosolic LPS sensing triggered the release of galectin-1, a β-galactoside-binding lectin. Galectin-1 release is a common feature of inflammatory cell death, including necroptosis. In vivo studies using galectin-1-deficient mice, recombinant galectin-1 and galectin-1-neutralizing antibody showed that galectin-1 promotes inflammation and plays a detrimental role in LPS-induced lethality. Mechanistically, galectin-1 inhibition of CD45 (Ptprc) underlies its unfavorable role in endotoxin shock. Finally, we found increased galectin-1 in sera from human patients with sepsis. Overall, we uncovered galectin-1 as a bona fide DAMP released as a consequence of cytosolic LPS sensing, identifying a new outcome of inflammatory cell death.
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形成孔的蛋白质加油D可以调节白细胞介素-1的巨噬细胞分泌。
影响因子：
32.4
作者：
Evavold CL;Ruan J;Tan Y;Xia S;Wu H;Kagan JC
通讯作者：
Kagan JC
DOI：
10.1073/pnas.1922778117
发表时间：
2020-03-24
影响因子：
11.1
作者：
Martinez Allo, Veronica C.;Hauk, Vanesa;Toscano, Marta A.
通讯作者：
Toscano, Marta A.
DOI：
10.1126/science.1240988
发表时间：
2013-09-13
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Hagar JA;Powell DA;Aachoui Y;Ernst RK;Miao EA
通讯作者：
Miao EA
影响因子：
2.9
作者：
Di Lella, Santiago;Sundblad, Victoria;Cerliani, Juan P.;Guardia, Carlos M.;Estrin, Dario A.;Vasta, Gerardo R.;Rabinovich, Gabriel A.
通讯作者：
Rabinovich, Gabriel A.
影响因子：
7.4
作者：
Huang, Xiao-Ting;Liu, Wei;Tang, Si-Yuan
通讯作者：
Tang, Si-Yuan